Vitamin D testing and the use of vitamin D supplements have increased substantially in
recent years. Currently, the role of vitamin D supplementation, and the optimal vitamin D …

The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of
25-hydroxyvitamin D and other metabolites, including 1, 25 (OH) 2D, the ligand for the …

Background It is unclear whether supplementation with vitamin D reduces the risk of cancer
or cardiovascular disease, and data from randomized trials are limited. Methods We …

1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …

Sepsis, severe sepsis, and septic shock represent increasingly severe systemic
inflammatory responses to infection. Sepsis is common in the aging population, and it …

It is now generally accepted that vitamin D deficiency is a worldwide health problem that
affects not only musculoskeletal health but also a wide range of acute and chronic diseases …

Vitamin D deficiency has a high worldwide prevalence, but actions to improve this public
health problem are challenged by the heterogeneity of nutritional and clinical vitamin D …

Vitamin D is not really a vitamin but the precursor to the potent steroid hormone calcitriol,
which has widespread actions throughout the body. Calcitriol regulates numerous cellular …

Low serum concentrations of 25-hydroxyvitamin D (25 [OH] D) have been associated with
many non-skeletal disorders. However, whether low 25 (OH) D is the cause or result of ill …

Importance Cardiovascular disease and cancer are the 2 leading causes of death in the US,
and vitamin and mineral supplementation has been proposed to help prevent these …