Digital twins for health: a sco** review

E Katsoulakis, Q Wang, H Wu, L Shahriyari… - NPJ digital …, 2024 - nature.com
The use of digital twins (DTs) has proliferated across various fields and industries, with a
recent surge in the healthcare sector. The concept of digital twin for health (DT4H) holds …

Generative artificial intelligence empowers digital twins in drug discovery and clinical trials

M Bordukova, N Makarov… - Expert opinion on …, 2024 - Taylor & Francis
ABSTRACT Introduction The concept of Digital Twins (DTs) translated to drug development
and clinical trials describes virtual representations of systems of various complexities …

[HTML][HTML] Impactful digital twin in the healthcare revolution

H Hassani, X Huang, S MacFeely - Big Data and Cognitive Computing, 2022 - mdpi.com
Over the last few decades, our digitally expanding world has experienced another significant
digitalization boost because of the COVID-19 pandemic. Digital transformations are …

Integrating machine learning and multiscale modeling—perspectives, challenges, and opportunities in the biological, biomedical, and behavioral sciences

M Alber, A Buganza Tepole, WR Cannon, S De… - NPJ digital …, 2019 - nature.com
Fueled by breakthrough technology developments, the biological, biomedical, and
behavioral sciences are now collecting more data than ever before. There is a critical need …

The digital twin in medicine: a key to the future of healthcare?

T Sun, X He, X Song, L Shu, Z Li - Frontiers in Medicine, 2022 - frontiersin.org
There is a growing need for precise diagnosis and personalized treatment of disease in
recent years. Providing treatment tailored to each patient and maximizing efficacy and …

Digital twins: The new frontier for personalized medicine?

M Cellina, M Cè, M Alì, G Irmici, S Ibba, E Caloro… - Applied Sciences, 2023 - mdpi.com
Digital twins are virtual replicas of physical objects or systems. This new technology is
increasingly being adopted in industry to improve the monitoring and efficiency of products …

The openCARP simulation environment for cardiac electrophysiology

G Plank, A Loewe, A Neic, C Augustin… - Computer methods and …, 2021 - Elsevier
Abstract Background and Objective: Cardiac electrophysiology is a medical specialty with a
long and rich tradition of computational modeling. Nevertheless, no community standard for …

Recreating the heart's helical structure-function relationship with focused rotary jet spinning

H Chang, Q Liu, JF Zimmerman, KY Lee, Q **… - Science, 2022 - science.org
Helical alignments within the heart's musculature have been speculated to be important in
achieving physiological pum** efficiencies. Testing this possibility is difficult, however …

[HTML][HTML] A comprehensive and biophysically detailed computational model of the whole human heart electromechanics

M Fedele, R Piersanti, F Regazzoni, M Salvador… - Computer Methods in …, 2023 - Elsevier
While ventricular electromechanics is extensively studied in both physiological and
pathological conditions, four-chamber heart models have only been addressed recently; …

A mathematical model that integrates cardiac electrophysiology, mechanics, and fluid dynamics: Application to the human left heart

M Bucelli, A Zingaro, PC Africa… - … journal for numerical …, 2023 - Wiley Online Library
We propose a mathematical and numerical model for the simulation of the heart function that
couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and …