The causative agent of tuberculosis (TB), Mycobacterium tuberculosis and more recently
totally drug‐resistant strains of M. tuberculosis, display unique mechanisms to survive in the …

Two parallel revolutions were born in the golden era of antibiotics (~ 1940 to 1960). One
was a revolution in medicine as physicians went to war with microbes. The second was a …

Our team had previously identified certain indolecarboxamides that represented a new
chemical scaffold that showed promising anti-TB activity at both an in vitro and in vivo level …

Piperazine, is privileged six membered nitrogen containing heterocyclic ring also known as
1, 4-Diazacyclohexane. Consequently, piperazine is a versatile medicinally important …

Tuberculosis (TB) remains one of the leading causes of mortality and morbidity worldwide,
with approximately one-third of the world's population infected with latent TB. This is further …

The genus Mycobacterium comprises a group of obligately aerobic bacteria that have
adapted to inhabit a wide range of intracellular and extracellular environments …

New 2-pyrrolamidobenzothiazole-based inhibitors of mycobacterial DNA gyrase were
discovered. Among these, compounds 49 and 51, show excellent antibacterial activity …

The modulation of DNA topology by DNA gyrase and topoisomerase IV, both of which are
type IIA topoisomerases and found in most bacteria, is a function vital to DNA replication …

Quinoline and its derivatives comprise an important group of heterocyclic compounds that
exhibits a wide range of pharmacological properties such as antibacterial, antiviral …

Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …