High-throughput sequencing-based methods and their applications in the study of
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …

Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …

Transcription factors (TFs) orchestrate the gene expression programs that define each cell's
identity. The canonical TF accomplishes this with two domains, one that binds specific DNA …

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype with the
worst prognosis and few effective therapies. Here we identified MS023, an inhibitor of type I …

Most human genes generate multiple transcript isoforms. The differential expression of these
isoforms can help specify cell types. Diverse transcript isoforms arise from the use of …

Understanding the mechanisms of pre-mRNA splicing is limited by the technical challenges
to examining spliceosomes in vivo. Here, we report the isolation of RNP complexes derived …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein is
essential for viral replication, making it a promising target for antiviral drug and vaccine …

Chemoresistance remains a major complication of cancer treatments. Recent data provide
strong evidence that chemoresistance is linked to epithelial–mesenchymal transition (EMT) …

The spliceosome is the complex molecular machinery that sequentially assembles on
eukaryotic messenger RNA precursors to remove introns (pre-mRNA splicing), a …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …