Clinical trials with mesenchymal stem cells: an update

T Squillaro, G Peluso, U Galderisi - Cell transplantation, 2016 - journals.sagepub.com
In the last year, the promising features of mesenchymal stem cells (MSCs), including their
regenerative properties and ability to differentiate into diverse cell lineages, have generated …

Role of neuroinflammation in amyotrophic lateral sclerosis: cellular mechanisms and therapeutic implications

J Liu, F Wang - Frontiers in immunology, 2017 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects
upper motor neurons (MNs) comprising the corticospinal tract and lower MNs arising from …

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

CS Constantinescu, N Farooqi… - British journal of …, 2011 - Wiley Online Library
Experimental autoimmune encephalomyelitis (EAE) is the most commonly used
experimental model for the human inflammatory demyelinating disease, multiple sclerosis …

Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis

D Karussis, C Karageorgiou… - Archives of …, 2010 - jamanetwork.com
Objective To evaluate the feasibility, safety, and immunological effects of intrathecal and
intravenous administration of autologous mesenchymal stem cells (MSCs)(also …

Neuroprotection and immunomodulation with mesenchymal stem cells in chronic experimental autoimmune encephalomyelitis

I Kassis, N Grigoriadis, B Gowda-Kurkalli… - Archives of …, 2008 - jamanetwork.com
Objective To investigate the therapeutic potential of mesenchymal stromal cells (MSCs) in
the chronic model of experimental autoimmune encephalomyelitis (EAE). Design …

Brain regeneration in physiology and pathology: the immune signature driving therapeutic plasticity of neural stem cells

G Martino, S Pluchino, L Bonfanti… - Physiological …, 2011 - journals.physiology.org
Regenerative processes occurring under physiological (maintenance) and pathological
(reparative) conditions are a fundamental part of life and vary greatly among different …

Interferon-γ regulates the proliferation and differentiation of mesenchymal stem cells via activation of indoleamine 2, 3 dioxygenase (IDO)

J Croitoru-Lamoury, FMJ Lamoury, M Caristo, K Suzuki… - PloS one, 2011 - journals.plos.org
The kynurenine pathway (KP) of tryptophan metabolism is linked to antimicrobial activity and
modulation of immune responses but its role in stem cell biology is unknown. We show that …

Animal models of multiple sclerosis—potentials and limitations

E Mix, H Meyer-Rienecker, HP Hartung… - Progress in neurobiology, 2010 - Elsevier
Experimental autoimmune encephalomyelitis (EAE) is still the most widely accepted animal
model of multiple sclerosis (MS). Different types of EAE have been developed in order to …

Neural precursors attenuate autoimmune encephalomyelitis by peripheral immunosuppression

O Einstein, N Fainstein, I Vaknin… - Annals of Neurology …, 2007 - Wiley Online Library
Objective Intracerebroventricular or intravenous (IV) injection of neural precursor cells
(NPCs) attenuates experimental autoimmune encephalomyelitis (EAE), the animal model of …

Human neural stem cells ameliorate autoimmune encephalomyelitis in non‐human primates

S Pluchino, A Gritti, E Blezer, S Amadio… - Annals of Neurology …, 2009 - Wiley Online Library
Objective Transplanted neural stem/precursor cells (NPCs) display peculiar therapeutic
plasticity in vivo. Although the replacement of cells was first expected as the prime …