Asthma is a chronic inflammatory disorder of the airways. While the local infiltration of
eosinophils and mast cells, and their role in the disease have long been recognized …

Pseudomonas aeruginosa (P. aeruginosa) is a ubiquitous and opportunistic microorganism
and is considered one of the most significant pathogens that produce chronic colonization …

Severe asthma (SA) is a challenge to control, as patients are not responsive to high doses of
systemic corticosteroids (CS). In contrast, mild-moderate asthma (MMA) is responsive to low …

Asthma is a common heterogeneous disease with a complex pathophysiology that carries a
significant mortality rate and high morbidity. Current therapies based on inhaled …

There has been long-standing interest in the role of bacterial communities in the complex
and heterogeneous disease of asthma. With the advent of 16s rRNA sequencing replacing …

Background The lower airways harbor a community of bacterial species which is altered in
asthma. Objectives We examined whether the lower airway microbiota were related to …

The importance of the microbiome, and of the gut-lung axis in the origin and persistence of
asthma, is an ongoing field of investigation. The process of microbial colonisation in the first …

Asthma encompasses a variety of clinical phenotypes that involve distinct T cell–driven
inflammatory processes. Improved understanding of human T-cell biology and the influence …

Background Bacteria are frequently cultured from sputum samples of severe asthma patients
suggesting a defect in bacterial clearance from the airway. We measured the capacity of …

Exacerbations of symptoms represent an unmet need for people with asthma. Bacterial
dysbiosis and opportunistic bacterial infections have been observed in, and may contribute …