Proteases enzymatically hydrolyze peptide bonds in substrate proteins, resulting in a
widespread, irreversible posttranslational modification of the protein's structure and …

Pulpitis is the inflammatory response of the dental pulp to a tooth insult, whether it is
microbial, chemical, or physical in origin. It is traditionally referred to as reversible or …

Protein N termini unambiguously identify truncated, alternatively translated or modified
proteoforms with distinct functions and reveal perturbations in disease. Selective enrichment …

Introduction: Numerous diseases are caused by changes in post-translational modifications
(PTMs). Therefore, the number of clinical proteomics studies that include the analysis of …

The HUPO Human Proteome Project (HPP) has two overall goals:(1) stepwise completion of
the protein parts list the draft human proteome including confidently identifying and …

Mass spectrometry based proteomics is an indispensable tool for almost all research areas
relevant for the understanding of proteolytic processing, ranging from the identification of …

The Human Proteome Project (HPP) annually reports on progress throughout the field in
credibly identifying and characterizing the human protein parts list and making proteomics …

Deregulated cathepsin proteolysis occurs across numerous cancers, but in vivo substrates
mediating tumorigenesis remain ill-defined. Applying 8-plex iTRAQ terminal amine isotopic …

Applications of proteomics tools revolutionized various biomedical disciplines such as
genetics, molecular biology, medicine, and dentistry. The aim of this review is to highlight the …

Various forms of protein (proteoforms) are generated by genetic variations, alternative
splicing, alternative translation initiation, co-or post-translational modification and …