Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive
intra-tumoral heterogeneity, and frequently develops resistance to therapies. Tumor …

Simple Summary Epigenetic therapies are promising agents for overcoming clinical
resistance to conventional treatments in breast cancer. In the assessed trials, the use of …

Inducible nitric oxide synthase (NOS2) produces high local concentrations of nitric oxide
(NO), and its expression is associated with inflammation, cellular stress signals, and cellular …

Epigenetic changes are known to accrue in normal cells as a result of ageing and
cumulative exposure to cancer risk factors. Increasing evidence points towards age-related …

Breast cancer remains the most frequently diagnosed cancer in women worldwide. Delayed
presentation of the disease, late stage at diagnosis, limited therapeutic options, metastasis …

Circulating tumor cells (CTCs) play a pivotal role in metastasis, the leading cause of cancer-
associated death. Recent improvements of CTC isolation tools, coupled with a steady …

Epigenetic modifications have long been recognized as an essential level in transcriptional
regulation linking behavior and environmental conditions or stimuli with biological …

Ubiquitous to normal female human somatic cells, X-chromosome inactivation (XCI) tightly
regulates the transcriptional silencing of a single X chromosome from each pair. Some …

The field of cancer genomics and transcriptomics has evolved from targeted profiling to swift
sequencing of individual tumor genome and transcriptome. The steady growth in genome …

Most of the cancer-associated mortality and morbidity can be attributed to metastasis. The
role of epigenetic and epitranscriptomic alterations in cancer origin and progression has …