Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with
intrinsic abilities to identify and eliminate virally infected cells and tumour cells. Possessing …

The advent of chimeric antigen receptor (CAR) T cell therapy has resulted in unprecedented
long-term clearance of relapse/refractory hematological malignancies in both pediatric and …

Natural killer (NK) cells display a unique inherent ability to identify and eliminate virus-
infected cells and tumor cells. They are particularly powerful for elimination of hematological …

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer.
Transforming growth factor beta (TGF-β) is highly expressed in the liver tumor …

During this last decade, adoptive transfer of T lymphocytes genetically modified to express
chimeric antigen receptors (CARs) emerged as a valuable therapeutic strategy in …

Small extracellular vesicles (sEV) derived from diverse natural killer (NK) cell lines have
proven their exceptional antitumor activities. However, sEV from human primary NK cells …

Myeloid-derived suppressor cells (MDSCs) are immune cells of the myeloid lineage that
progressively accumulate in tumors and play an important role in promoting tumor growth …

Extracellular vesicles (EVs) play a pivotal role in intercellular communication and have been
implicated in cancer progression. Hypoxia, a pervasive hallmark of cancer, is known to …

Despite promising results shown in hematologic tumors, immunotherapies for the treatment
of solid tumors have mostly failed so far. The immunosuppressive tumor microenvironment …

Lung cancer remains among the most difficult-to-treat malignancies and is the leading cause
of cancer-related deaths worldwide. The introduction of targeted therapies and checkpoint …