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Laboratory approach to hemolytic anemia
Hemolytic anemias are a group of disorders with varied clinical and molecular
heterogeneity. They are characterized by decreased levels of circulating erythrocytes in …
heterogeneity. They are characterized by decreased levels of circulating erythrocytes in …
Old and new insights into the diagnosis of hereditary spherocytosis
Hereditary spherocytosis (HS) belongs to the group of congenital hemolytic anemias
resulting from plasma membrane protein deficiency. When diagnosed too late, HS bares the …
resulting from plasma membrane protein deficiency. When diagnosed too late, HS bares the …
Advances in laboratory diagnosis of hereditary spherocytosis
Among the red cell membrane disorders, hereditary spherocytosis (HS) is one of the most
common causes of inherited hemolytic anemia. HS results from the deficiency or dysfunction …
common causes of inherited hemolytic anemia. HS results from the deficiency or dysfunction …
Deciphering molecular heterogeneity of Indian families with hereditary spherocytosis using targeted next‐generation sequencing: first South Asian study
Defects in various erythrocyte membrane proteins genes (ankyrin, band‐3, β‐and α‐spectrin
and protein 4· 2) can cause hereditary spherocytosis (HS). This molecular heterogeneity of …
and protein 4· 2) can cause hereditary spherocytosis (HS). This molecular heterogeneity of …
Flow cytometric osmotic fragility test and eosin‐5'‐maleimide dye‐binding tests are better than conventional osmotic fragility tests for the diagnosis of hereditary …
Introduction Hereditary spherocytosis (HS) is the most common inherited hemolytic anemia
with heterogeneous clinico‐laboratory manifestations. We evaluated the flow‐cytometric …
with heterogeneous clinico‐laboratory manifestations. We evaluated the flow‐cytometric …
Overview on hereditary spherocytosis diagnosis
A Polizzi, LP Dicembre, C Failla… - International Journal …, 2025 - Wiley Online Library
Introduction Hereditary spherocytosis (HS) is a congenital haemolytic disorder, resulting
from plasma membrane protein deficiency of red blood cells (RBCs). Typical pathological …
from plasma membrane protein deficiency of red blood cells (RBCs). Typical pathological …
[HTML][HTML] Next-generation sequencing–based diagnosis of unexplained inherited hemolytic anemias reveals wide genetic and phenotypic heterogeneity
Determination of the cause of inherited hemolysis is based on clinical and stepwise
conventional laboratory tests. Patients with obscure etiology require genetic diagnosis …
conventional laboratory tests. Patients with obscure etiology require genetic diagnosis …
Screening tools for hereditary hemolytic anemia: new concepts and strategies
E Fermo, C Vercellati, P Bianchi - Expert review of hematology, 2021 - Taylor & Francis
Introduction Hereditary hemolytic anemias are a group of rare and heterogeneous disorders
due to abnormalities in structure, metabolism, and transport functions of erythrocytes; they …
due to abnormalities in structure, metabolism, and transport functions of erythrocytes; they …
[HTML][HTML] Optimal reference gene selection for expression studies in human reticulocytes
Reference genes are indispensable for normalizing mRNA levels across samples in real-
time quantitative PCR. Their expression levels vary under different experimental conditions …
time quantitative PCR. Their expression levels vary under different experimental conditions …
Facilitating EMA binding test performance using fluorescent beads combined with next‐generation sequencing
Abstract The eosin‐5′‐maleimide (EMA) binding test is widely used as diagnostic test for
hereditary spherocytosis (HS), one of the most common haemolytic disorders in Caucasian …
hereditary spherocytosis (HS), one of the most common haemolytic disorders in Caucasian …