Type I Interferons (IFNs) induce the expression of> 500 genes, which are collectively called
ISGs (IFN-stimulated genes). One of the earliest ISGs induced by IFNs is ISG15 (Interferon …

Interferons (IFNs) bind to cell surface receptors and activate the expression of interferon-
stimulated genes (ISGs) through intracellular signaling cascades. ISGs and their expression …

The causes of grey matter pathology and diffuse neuron injury in MS remain incompletely
understood. Axonal stress signals arising from white matter lesions has been suggested to …

Post-translational modification (PTMs) of proteins by ubiquitin and ubiquitin-like modifiers
such as interferon-stimulated gene 15 (ISG15) and small ubiquitin-related modifier (SUMO) …

Mitophagy is defective in several neurodegenerative diseases, including Ataxia
Telangiectasia (AT). However, the molecular mechanism underlying defective mitophagy in …

Alzheimer disease (AD), a prevalent neurodegenerative condition in the elderly, is marked
by a deficit in macroautophagy/autophagy, leading to intracellular MAPT/tau accumulation …

Better understanding of the earliest molecular pathologies of all neurodegenerative
diseases is expected to improve human therapeutics. We investigated the earliest molecular …

ISGylation is a well-established antiviral mechanism, but its specific function in immune and
tissue homeostasis regulation remains elusive. Here, we reveal that the RNA-binding …

Methamphetamine (METH) is a highly abused substance on a global scale and has the
capacity to elicit toxicity within the central nervous system. The neurotoxicity induced by …

CLEC16A has been shown to play a role in autophagy/mitophagy processes. Additionally,
genetic variants in CLEC16A have been implicated in multiple autoimmune diseases. We …