Highlights•Providing concepts and generation processes of chemical fingerprints.•
Comparing the algorithms and characteristics among different types of fingerprints.• …

Natural products have served as powerful therapeutics against pathogenic bacteria since
the golden age of antibiotics of the mid-20th century. However, the increasing frequency of …

The looming antibiotic-resistance crisis has penetrated the consciousness of clinicians,
researchers, policymakers, politicians and the public at large. The evolution and widespread …

Dangerous, antibiotic resistant bacteria have been observed with increasing frequency over
the past several decades. In this review the factors that have been linked to this …

There is a continuous need for iterative cycles of antibiotic discovery and development to
deal with the selection of resistant pathogens that emerge as therapeutic application of an …

Biologically active molecules can be identified through the screening of small-molecule
libraries. Deficiencies in current compound collections are evidenced by the continuing …

The role and contributions of natural products chemistry in advancements of the physical
and biological sciences, its interdisciplinary domains, and emerging of new avenues by …

The discovery of novel antibiotic classes has not kept pace with the growing threat of
bacterial resistance. Antibiotic candidates that act at new targets or via distinct mechanisms …

An unfailing observation over the past 70 years is that resistance to all antibiotics emerges
eventually after use in the clinic. Where does this resistance come from? Recent work has …

The key role of the bacterial ribosome makes it an important target for antibacterial agents.
Indeed, a large number of clinically useful antibiotics target this complex translational …