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Bacterial persisters: molecular mechanisms and therapeutic development
H Niu, J Gu, Y Zhang - Signal transduction and targeted therapy, 2024 - nature.com
Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …
bacteria that survive in stress environments such as antibiotic exposure, acidic and …
The DNA damage inducible SOS response is a key player in the generation of bacterial persister cells and population wide tolerance
Z Podlesek, D Žgur Bertok - Frontiers in microbiology, 2020 - frontiersin.org
Population-wide tolerance and persisters enable susceptible bacterial cells to endure
hostile environments, including antimicrobial exposure. The SOS response can play a …
hostile environments, including antimicrobial exposure. The SOS response can play a …
Antibiotic combinations reduce Staphylococcus aureus clearance
The spread of antibiotic resistance is attracting increased attention to combination-based
treatments. Although drug combinations have been studied extensively for their effects on …
treatments. Although drug combinations have been studied extensively for their effects on …
Cascade‐targeting poly (amino acid) nanoparticles eliminate intracellular bacteria via on‐site antibiotic delivery
W Feng, G Li, X Kang, R Wang, F Liu… - Advanced …, 2022 - Wiley Online Library
Intracellular bacteria in latent or dormant states tolerate high‐dose antibiotics. Fighting
against these opportunistic bacteria has been a long‐standing challenge. Herein, the design …
against these opportunistic bacteria has been a long‐standing challenge. Herein, the design …
Nanophysical antimicrobial strategies: a rational deployment of nanomaterials and physical stimulations in combating bacterial infections
The emergence of bacterial resistance due to the evolution of microbes under antibiotic
selection pressure, and their ability to form biofilm, has necessitated the development of …
selection pressure, and their ability to form biofilm, has necessitated the development of …
Single-cell massively-parallel multiplexed microbial sequencing (M3-seq) identifies rare bacterial populations and profiles phage infection
Bacterial populations are highly adaptive. They can respond to stress and survive in shifting
environments. How the behaviours of individual bacteria vary during stress, however, is …
environments. How the behaviours of individual bacteria vary during stress, however, is …
Staphylococcal trafficking and infection—from 'nose to gut'and back
EJM Raineri, D Altulea… - FEMS microbiology …, 2022 - academic.oup.com
Staphylococcus aureus is an opportunistic human pathogen, which is a leading cause of
infections worldwide. The challenge in treating S. aureus infection is linked to the …
infections worldwide. The challenge in treating S. aureus infection is linked to the …
Decline in nitrosative stress drives antibiotic persister regrowth during infection
Internalization of pathogenic bacteria by macrophages results in formation of antibiotic-
tolerant persisters. These cells are maintained in a non-growing state for extended periods …
tolerant persisters. These cells are maintained in a non-growing state for extended periods …
A natural killer cell mimic against intracellular pathogen infections
In the competition between the pathogen infection and the host defense, infectious
microorganisms may enter the host cells by evading host defense mechanisms and use the …
microorganisms may enter the host cells by evading host defense mechanisms and use the …
Oxygen‐Deficient Bioceramics: Combination of Diagnosis, Therapy, and Regeneration
The journey of ceramics in medicine has been synchronized with an evolution from the first
generation—alumina, zirconia, etc.—to the third—3D scaffolds. There is an up‐and‐coming …
generation—alumina, zirconia, etc.—to the third—3D scaffolds. There is an up‐and‐coming …