Bacterial persisters: molecular mechanisms and therapeutic development

H Niu, J Gu, Y Zhang - Signal transduction and targeted therapy, 2024 - nature.com
Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …

The DNA damage inducible SOS response is a key player in the generation of bacterial persister cells and population wide tolerance

Z Podlesek, D Žgur Bertok - Frontiers in microbiology, 2020 - frontiersin.org
Population-wide tolerance and persisters enable susceptible bacterial cells to endure
hostile environments, including antimicrobial exposure. The SOS response can play a …

Antibiotic combinations reduce Staphylococcus aureus clearance

V Lázár, O Snitser, D Barkan, R Kishony - Nature, 2022 - nature.com
The spread of antibiotic resistance is attracting increased attention to combination-based
treatments. Although drug combinations have been studied extensively for their effects on …

Cascade‐targeting poly (amino acid) nanoparticles eliminate intracellular bacteria via on‐site antibiotic delivery

W Feng, G Li, X Kang, R Wang, F Liu… - Advanced …, 2022 - Wiley Online Library
Intracellular bacteria in latent or dormant states tolerate high‐dose antibiotics. Fighting
against these opportunistic bacteria has been a long‐standing challenge. Herein, the design …

Nanophysical antimicrobial strategies: a rational deployment of nanomaterials and physical stimulations in combating bacterial infections

B Jia, X Du, W Wang, Y Qu, X Liu, M Zhao… - Advanced …, 2022 - Wiley Online Library
The emergence of bacterial resistance due to the evolution of microbes under antibiotic
selection pressure, and their ability to form biofilm, has necessitated the development of …

Single-cell massively-parallel multiplexed microbial sequencing (M3-seq) identifies rare bacterial populations and profiles phage infection

B Wang, AE Lin, J Yuan, KE Novak, MD Koch… - Nature …, 2023 - nature.com
Bacterial populations are highly adaptive. They can respond to stress and survive in shifting
environments. How the behaviours of individual bacteria vary during stress, however, is …

Staphylococcal trafficking and infection—from 'nose to gut'and back

EJM Raineri, D Altulea… - FEMS microbiology …, 2022 - academic.oup.com
Staphylococcus aureus is an opportunistic human pathogen, which is a leading cause of
infections worldwide. The challenge in treating S. aureus infection is linked to the …

Decline in nitrosative stress drives antibiotic persister regrowth during infection

S Ronneau, C Michaux, S Helaine - Cell Host & Microbe, 2023 - cell.com
Internalization of pathogenic bacteria by macrophages results in formation of antibiotic-
tolerant persisters. These cells are maintained in a non-growing state for extended periods …

A natural killer cell mimic against intracellular pathogen infections

M Ge, Z Ruan, YX Zhu, W Wu, C Yang, H Lin, J Shi - Science Advances, 2024 - science.org
In the competition between the pathogen infection and the host defense, infectious
microorganisms may enter the host cells by evading host defense mechanisms and use the …

Oxygen‐Deficient Bioceramics: Combination of Diagnosis, Therapy, and Regeneration

A Bigham, MG Raucci, K Zheng… - Advanced …, 2023 - Wiley Online Library
The journey of ceramics in medicine has been synchronized with an evolution from the first
generation—alumina, zirconia, etc.—to the third—3D scaffolds. There is an up‐and‐coming …