Since techniques for cardiomyocyte isolation were first developed 35years ago, experiments
on single myocytes have yielded great insight into their cellular and sub-cellular physiology …

Calcium (Ca) is a universal intracellular second messenger. In muscle, Ca is best known for
its role in contractile activation. However, in recent years the critical role of Ca in other …

Routine use of diuretics and neurohumoral activation make hypokalemia (serum K+< 3. 5
mM) a prevalent electrolyte disorder among heart failure patients, contributing to the …

In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …

Sodium–calcium exchange (NCX) is the major calcium (Ca) efflux mechanism of ventricular
cardiomyocytes. Consequently the exchanger plays a critical role in the regulation of cellular …

Electrophysiological studies of the human heart face the fundamental challenge that
experimental data can be acquired only from patients with underlying heart disease …

Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

Abstract Free Calcium (Ca 2+) is an important and universal signalling entity in all cells, red
blood cells included. Although mature mammalian red blood cells are believed to not …

The sarco (endo) plasmic reticulum calcium ATPase 2 (SERCA2) transports Ca2+ from
cytosol into the sarcoplasmic reticulum (SR) of cardiomyocytes, thereby maintaining the …

Confocal and total internal reflection fluorescence imaging was used to examine the
distribution of caveolin-3, sodium-calcium exchange (NCX) and ryanodine receptors (RyRs) …