Protein sequence analysis using the MPI bioinformatics toolkit

F Gabler, SZ Nam, S Till, M Mirdita… - Current Protocols in …, 2020 - Wiley Online Library
Abstract The MPI Bioinformatics Toolkit (https://toolkit. tuebingen. mpg. de) provides
interactive access to a wide range of the best‐performing bioinformatics tools and …

The PSIPRED protein analysis workbench: 20 years on

DWA Buchan, DT Jones - Nucleic acids research, 2019 - academic.oup.com
The PSIPRED Workbench is a web server offering a range of predictive methods to the
bioscience community for 20 years. Here, we present the work we have completed to update …

A completely reimplemented MPI bioinformatics toolkit with a new HHpred server at its core

L Zimmermann, A Stephens, SZ Nam, D Rau… - Journal of molecular …, 2018 - Elsevier
Abstract The MPI Bioinformatics Toolkit (https://toolkit. tuebingen. mpg. de) is a free, one-stop
web service for protein bioinformatic analysis. It currently offers 34 interconnected external …

Systematic discovery of antiphage defense systems in the microbial pangenome

S Doron, S Melamed, G Ofir, A Leavitt, A Lopatina… - Science, 2018 - science.org
INTRODUCTION Bacteria and archaea are frequently attacked by viruses (phages) and as a
result have developed multiple, sophisticated lines of active defense that can collectively be …

Eukaryotic copper-only superoxide dismutases (SODs): A new class of SOD enzymes and SOD-like protein domains

NG Robinett, RL Peterson, VC Culotta - Journal of Biological Chemistry, 2018 - ASBMB
The copper-containing superoxide dismutases (SODs) represent a large family of enzymes
that participate in the metabolism of reactive oxygen species by disproportionating …

Global analysis of protein folding using massively parallel design, synthesis, and testing

GJ Rocklin, TM Chidyausiku, I Goreshnik, A Ford… - Science, 2017 - science.org
Proteins fold into unique native structures stabilized by thousands of weak interactions that
collectively overcome the entropic cost of folding. Although these forces are “encoded” in the …

The world according to GARP transcription factors

A Safi, A Medici, W Szponarski, S Ruffel… - Current opinion in plant …, 2017 - Elsevier
Highlights•GARP family contains genes with very diverse in planta functions.•GARP family
may contain nutrient sensor proteins.•GARP TF could act as pioneer TFs.•GARP TF are thus …

The centrosome is a selective condensate that nucleates microtubules by concentrating tubulin

JB Woodruff, BF Gomes, PO Widlund, J Mahamid… - Cell, 2017 - cell.com
Centrosomes are non-membrane-bound compartments that nucleate microtubule arrays.
They consist of nanometer-scale centrioles surrounded by a micron-scale, dynamic …

Cryptic inoviruses revealed as pervasive in bacteria and archaea across Earth's biomes

S Roux, M Krupovic, RA Daly, AL Borges… - Nature …, 2019 - nature.com
Bacteriophages from the Inoviridae family (inoviruses) are characterized by their unique
morphology, genome content and infection cycle. One of the most striking features of …

Phosphoribosylation of ubiquitin promotes serine ubiquitination and impairs conventional ubiquitination

S Bhogaraju, S Kalayil, Y Liu, F Bonn, T Colby, I Matic… - Cell, 2016 - cell.com
Conventional ubiquitination involves the ATP-dependent formation of amide bonds between
the ubiquitin C terminus and primary amines in substrate proteins. Recently, SdeA, an …