Recent progress in functionalized and targeted polymersomes and chimeric polymeric nanotheranostic platforms for cancer therapy

M Beygi, F Oroojalian, SS Hosseini… - Progress in Materials …, 2023 - Elsevier
The majority of advances in cancer therapy have been achieved based on developments in
public awareness, as well as novel diagnostic and therapeutic modalities. Treatment …

pH-responsive polymersome-mediated delivery of doxorubicin into tumor sites enhances the therapeutic efficacy and reduces cardiotoxic effects

LJC Albuquerque, V Sincari, A Jäger, J Kucka… - Journal of Controlled …, 2021 - Elsevier
The delivery of therapeutics into sites of action by using cargo-delivery platforms potentially
minimizes their premature degradation and fast clearance from the bloodstream …

The in vivo fate of 225Ac daughter nuclides using polymersomes as a model carrier

RM Kruijff, R Raavé, A Kip, J Molkenboer-Kuenen… - Scientific reports, 2019 - nature.com
Increasing attention is given to personalized tumour therapy, where α-emitters can
potentially play an important role. Alpha particles are ideal for localized cell killing because …

Microfluidic-assisted engineering of quasi-monodisperse pH-responsive polymersomes toward advanced platforms for the intracellular delivery of hydrophilic …

LJC Albuquerque, V Sincari, A Ja? ger, R Konefa?… - Langmuir, 2019 - ACS Publications
The extracellular and subcellular compartments are characterized by specific pH levels that
can be modified by pathophysiological states. This scenario encourages the use of …

[HTML][HTML] Deep learning for automatic organ and tumor segmentation in nanomedicine pharmacokinetics

A Dhaliwal, J Ma, M Zheng, Q Lyu, MA Rajora, S Ma… - Theranostics, 2024 - ncbi.nlm.nih.gov
Rationale: Multimodal imaging provides important pharmacokinetic and dosimetry
information during nanomedicine development and optimization. However, accurate …

99mTc Radiolabeled HA/TPGS-Based Curcumin-Loaded Nanoparticle for Breast Cancer Synergistic Theranostics: Design, in vitro and in vivo Evaluation

C Huang, F Chen, L Zhang, Y Yang… - International journal of …, 2020 - Taylor & Francis
Background Emerging cancer therapy requires highly sensitive diagnosis in combination
with cancer-targeting therapy. In this study, a self-assembled pH-sensitive curcumin (Cur) …

[HTML][HTML] Uptake and subcellular distribution of radiolabeled polymersomes for radiotherapy

SJ Roobol, TA Hartjes, JA Slotman, RM de Kruijff… - …, 2020 - ncbi.nlm.nih.gov
Polymersomes have the potential to be applied in targeted alpha radionuclide therapy, while
in addition preventing release of recoiling daughter isotopes. In this study, we investigated …

Elucidating the influence of tumor presence on the polymersome circulation time in mice

RM de Kruijff, R Raavé, A Kip, J Molkenboer-Kuenen… - Pharmaceutics, 2019 - mdpi.com
The use of nanoparticles as tumor-targeting agents is steadily increasing, and the influence
of nanoparticle characteristics such as size and stealthiness have been established for a …

Self-assembled polymer systems responsive to external stimuli for biomedicine

V Sincari - 2022 - dspace.cuni.cz
The first work in my doctoral thesis described a novel rapid and eco-friendly reversible
addition-fragmentation chain transfer (RAFT) polymerization reaction of the N-(2 …

[PDF][PDF] Федеральное государственное бюджетное учреждение науки ФИЗИКО-ТЕХНИЧЕСКИЙ ИНСТИТУТ им. АФ ИОФФЕ Российской академии наук

ВПК НАНОКРИСТАЛЛАХ - ioffe.ru
Актуальность темы исследования. Полупроводниковые коллоидные на нокристаллы в
стекле [1, 2] и в водном растворе [3] были впервые синтезированы более 30 лет назад …