High-throughput methods are powerful tools to develop predictive models for assessing
drug-induced liver injury (DILI). However, the development of predictive models requires a …

Idiosyncratic drug-induced liver injury (DILI) is a type of hepatic injury caused by an
uncommon drug adverse reaction that can develop to conditions spanning from …

Background Conventional preclinical models often miss drug toxicities, meaning the harm
these drugs pose to humans is only realized in clinical trials or when they make it to market …

Drug-induced liver injury (DILI) continues to be a major source of clinical attrition,
precautionary warnings, and post-market withdrawal of drugs. Accordingly, there is a need …

The liver is an organ with critical importance for drug treatment as the disposition and
response to a given drug is often determined by its hepatic metabolism. Patient-specific …

Drug‐induced liver injury (DILI) is a major public health problem. Intrinsic (dose‐dependent)
DILI associated with acetaminophen overdose is the number one cause of acute liver failure …

Introduction: The liver is the most important target for drug-induced toxicity. This vulnerability
results from functional liver features and its role in the metabolic elimination of most drugs …

Adverse drug reactions (ADRs) are a common cause of attrition in drug discovery and
development and drug-induced liver injury (DILI) is a leading cause of preclinical and …

Conventional 2D drug screening often fails to accurately predict clinical outcomes. We
present an innovative approach to improve hepatotoxicity assessment by encapsulating …

Early identification of toxicity associated with new chemical entities (NCEs) is critical in
preventing late-stage drug development attrition. Liver injury remains a leading cause of …