Mitochondria are central hubs of cellular metabolism that also play key roles in signaling
and disease. It is therefore fundamentally important that mitochondrial quality and activity …

Efforts to understand how mitochondrial dysfunction contributes to neurodegeneration have
primarily focussed on the role of mitochondria in neuronal energy metabolism. However …

Mitochondria are central hubs of cellular metabolism and are tightly connected to signaling
pathways. The dynamic plasticity of mitochondria to fuse, divide, and contact other …

During nutrient stress, macroautophagy degrades cellular macromolecules, thereby
providing biosynthetic building blocks while simultaneously remodelling the proteome …

Selective autophagy specifically eliminates damaged or superfluous organelles, maintaining
cellular health. In this process, a double membrane structure termed an autophagosome …

Selective clearance of organelles, including endoplasmic reticulum (ER) and mitochondria,
by autophagy plays an important role in cell health. Here, we describe a developmentally …

Nix is a membrane‐anchored outer mitochondrial protein that induces mitophagy. While Nix
has an LC3‐interacting (LIR) motif that binds to ATG8 proteins, it also contains a minimal …

Neurons depend on autophagy to maintain cellular homeostasis, and defects in autophagy
are pathological hallmarks of neurodegenerative disease. To probe the role of basal …

Mitophagy must be carefully regulated to ensure that cells maintain appropriate numbers of
functional mitochondria. The SCFFBXL4 ubiquitin ligase complex suppresses mitophagy by …

The elucidation of the function of the PINK1 protein kinase and Parkin ubiquitin E3 ligase in
the elimination of damaged mitochondria by autophagy (mitophagy) has provided …