Epilepsy and epileptiform activity in late-onset Alzheimer disease: Clinical and pathophysiological advances, gaps and conundrums

A Kamondi, M Grigg-Damberger, W Löscher… - Nature Reviews …, 2024 - nature.com
A growing body of evidence has demonstrated a link between Alzheimer disease (AD) and
epilepsy. Late-onset epilepsy and epileptiform activity can precede cognitive deterioration in …

The fate of interneurons, GABAA receptor sub‐types and perineuronal nets in Alzheimer's disease

AB Ali, A Islam, A Constanti - Brain Pathology, 2023 - Wiley Online Library
Alzheimer's disease (AD) is the most common neurological disease, which is associated
with gradual memory loss and correlated with synaptic hyperactivity and abnormal …

Resting-state oscillations reveal disturbed excitation–inhibition ratio in Alzheimer's disease patients

AM Van Nifterick, D Mulder, DJ Duineveld… - Scientific reports, 2023 - nature.com
An early disruption of neuronal excitation–inhibition (E–I) balance in preclinical animal
models of Alzheimer's disease (AD) has been frequently reported, but is difficult to measure …

Regional precuneus cortical hyperexcitability in Alzheimer's disease patients

EP Casula, I Borghi, M Maiella… - Annals of …, 2023 - Wiley Online Library
Objective Neuronal excitation/inhibition (E/I) imbalance is a potential cause of neuronal
network malfunctioning in Alzheimer's disease (AD), contributing to cognitive dysfunction …

Epileptic activity on foramen ovale electrodes is associated with sleep and tau pathology in Alzheimer's disease

A Devulder, G Vanderlinden, L Van Langenhoven… - Brain, 2025 - academic.oup.com
Both sleep alterations and epileptiform activity are associated with the accumulation of
amyloid-β and tau pathology and are currently investigated for potential therapeutic …

Network hyperexcitability in early Alzheimer's disease: is functional connectivity a potential biomarker?

CJ Stam, AM van Nifterick, W de Haan, AA Gouw - Brain Topography, 2023 - Springer
Network hyperexcitability (NH) is an important feature of the pathophysiology of Alzheimer's
disease. Functional connectivity (FC) of brain networks has been proposed as a potential …

The clinical correlation between Alzheimer's disease and epilepsy

D Zhang, S Chen, S Xu, J Wu, Y Zhuang, W Cao… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease and epilepsy are common nervous system diseases in older adults, and
their incidence rates tend to increase with age. Patients with mild cognitive impairment and …

The significance of subclinical epileptiform activity in Alzheimer's disease: a review

EA Csernus, T Werber, A Kamondi… - Frontiers in …, 2022 - frontiersin.org
Hyperexcitability is a recently recognized contributor to the pathophysiology of Alzheimer's
disease (AD). Subclinical epileptiform activity (SEA) is a neurophysiological sign of cortical …

Latest advances in mechanisms of epileptic activity in Alzheimer's disease and dementia with Lewy Bodies

M Vicente, K Addo-Osafo, K Vossel - Frontiers in neurology, 2024 - frontiersin.org
Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) stand as the prevailing
sources of neurodegenerative dementia, impacting over 55 million individuals across the …

Alzheimer's Disease and Epilepsy: Exploring Shared Pathways and Promising Biomarkers for Future Treatments

AC Kalyvas, M Dimitriou, P Ioannidis… - Journal of Clinical …, 2024 - mdpi.com
Background: Alzheimer's disease (AD) and epilepsy represent two complex neurological
disorders with distinct clinical manifestations, yet recent research has highlighted their …