Epilepsy and epileptiform activity in late-onset Alzheimer disease: Clinical and pathophysiological advances, gaps and conundrums
A growing body of evidence has demonstrated a link between Alzheimer disease (AD) and
epilepsy. Late-onset epilepsy and epileptiform activity can precede cognitive deterioration in …
epilepsy. Late-onset epilepsy and epileptiform activity can precede cognitive deterioration in …
The fate of interneurons, GABAA receptor sub‐types and perineuronal nets in Alzheimer's disease
Alzheimer's disease (AD) is the most common neurological disease, which is associated
with gradual memory loss and correlated with synaptic hyperactivity and abnormal …
with gradual memory loss and correlated with synaptic hyperactivity and abnormal …
Resting-state oscillations reveal disturbed excitation–inhibition ratio in Alzheimer's disease patients
An early disruption of neuronal excitation–inhibition (E–I) balance in preclinical animal
models of Alzheimer's disease (AD) has been frequently reported, but is difficult to measure …
models of Alzheimer's disease (AD) has been frequently reported, but is difficult to measure …
Regional precuneus cortical hyperexcitability in Alzheimer's disease patients
Objective Neuronal excitation/inhibition (E/I) imbalance is a potential cause of neuronal
network malfunctioning in Alzheimer's disease (AD), contributing to cognitive dysfunction …
network malfunctioning in Alzheimer's disease (AD), contributing to cognitive dysfunction …
Epileptic activity on foramen ovale electrodes is associated with sleep and tau pathology in Alzheimer's disease
A Devulder, G Vanderlinden, L Van Langenhoven… - Brain, 2025 - academic.oup.com
Both sleep alterations and epileptiform activity are associated with the accumulation of
amyloid-β and tau pathology and are currently investigated for potential therapeutic …
amyloid-β and tau pathology and are currently investigated for potential therapeutic …
Network hyperexcitability in early Alzheimer's disease: is functional connectivity a potential biomarker?
Network hyperexcitability (NH) is an important feature of the pathophysiology of Alzheimer's
disease. Functional connectivity (FC) of brain networks has been proposed as a potential …
disease. Functional connectivity (FC) of brain networks has been proposed as a potential …
The clinical correlation between Alzheimer's disease and epilepsy
D Zhang, S Chen, S Xu, J Wu, Y Zhuang, W Cao… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease and epilepsy are common nervous system diseases in older adults, and
their incidence rates tend to increase with age. Patients with mild cognitive impairment and …
their incidence rates tend to increase with age. Patients with mild cognitive impairment and …
The significance of subclinical epileptiform activity in Alzheimer's disease: a review
EA Csernus, T Werber, A Kamondi… - Frontiers in …, 2022 - frontiersin.org
Hyperexcitability is a recently recognized contributor to the pathophysiology of Alzheimer's
disease (AD). Subclinical epileptiform activity (SEA) is a neurophysiological sign of cortical …
disease (AD). Subclinical epileptiform activity (SEA) is a neurophysiological sign of cortical …
Latest advances in mechanisms of epileptic activity in Alzheimer's disease and dementia with Lewy Bodies
M Vicente, K Addo-Osafo, K Vossel - Frontiers in neurology, 2024 - frontiersin.org
Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) stand as the prevailing
sources of neurodegenerative dementia, impacting over 55 million individuals across the …
sources of neurodegenerative dementia, impacting over 55 million individuals across the …
Alzheimer's Disease and Epilepsy: Exploring Shared Pathways and Promising Biomarkers for Future Treatments
AC Kalyvas, M Dimitriou, P Ioannidis… - Journal of Clinical …, 2024 - mdpi.com
Background: Alzheimer's disease (AD) and epilepsy represent two complex neurological
disorders with distinct clinical manifestations, yet recent research has highlighted their …
disorders with distinct clinical manifestations, yet recent research has highlighted their …