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Intratumor heterogeneity: the rosetta stone of therapy resistance
Advances in our understanding of molecular mechanisms of tumorigenesis have translated
into knowledge-based therapies directed against specific oncogenic signaling targets …
into knowledge-based therapies directed against specific oncogenic signaling targets …
Antioxidant and Prooxidant Nanozymes: From Cellular Redox Regulation to Next‐Generation Therapeutics
Nanozymes, nanomaterials with enzyme‐mimicking activity, have attracted tremendous
interest in recent years owing to their ability to replace natural enzymes in various …
interest in recent years owing to their ability to replace natural enzymes in various …
Biodegradable NIR‐II pseudo conjugate polymeric nanoparticles amplify photodynamic immunotherapy via alleviation of tumor hypoxia and tumor‐associated …
J Wan, X Zhang, D Tang, T Liu, H ** a simple and effective strategy to build a multi-functional …
Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations
Mutations, the fuel of evolution, are first manifested as rare DNA changes within a population
of cells. Although next-generation sequencing (NGS) technologies have revolutionized the …
of cells. Although next-generation sequencing (NGS) technologies have revolutionized the …
Promises and challenges of adoptive T-cell therapies for solid tumours
Cancer is a leading cause of death worldwide and, despite new targeted therapies and
immunotherapies, many patients with advanced-stage-or high-risk cancers still die, owing to …
immunotherapies, many patients with advanced-stage-or high-risk cancers still die, owing to …