Ventral tegmental area: cellular heterogeneity, connectivity and behaviour

M Morales, EB Margolis - Nature Reviews Neuroscience, 2017‏ - nature.com
Dopamine-releasing neurons of the ventral tegmental area (VTA) have central roles in
reward-related and goal-directed behaviours. VTA dopamine-releasing neurons are …

Navigating for reward

M Sosa, LM Giocomo - Nature Reviews Neuroscience, 2021‏ - nature.com
An organism's survival can depend on its ability to recall and navigate to spatial locations
associated with rewards, such as food or a home. Accumulating research has revealed that …

Map** projections of molecularly defined dopamine neuron subtypes using intersectional genetic approaches

JF Poulin, G Caronia, C Hofer, Q Cui, B Helm… - Nature …, 2018‏ - nature.com
Midbrain dopamine (DA) neurons have diverse functions that can in part be explained by
their heterogeneity. Although molecularly distinct subtypes of DA neurons have been …

Classification of midbrain dopamine neurons using single-cell gene expression profiling approaches

JF Poulin, Z Gaertner, OA Moreno-Ramos… - Trends in …, 2020‏ - cell.com
Dysfunctional dopamine (DA) signaling has been associated with a broad spectrum of
neuropsychiatric disorders, prompting investigations into how midbrain DA neuron …

[HTML][HTML] Striatal dopamine neurotransmission: regulation of release and uptake

D Sulzer, SJ Cragg, ME Rice - Basal ganglia, 2016‏ - Elsevier
Dopamine (DA) transmission is governed by processes that regulate release from axonal
boutons in the forebrain and the somatodendritic compartment in midbrain, and by …

Brain-wide correspondence of neuronal epigenomics and distant projections

J Zhou, Z Zhang, M Wu, H Liu, Y Pang, A Bartlett… - Nature, 2023‏ - nature.com
Single-cell analyses parse the brain's billions of neurons into thousands of 'cell-type'clusters
residing in different brain structures. Many cell types mediate their functions through targeted …

Functional consequences of neuropeptide and small-molecule co-transmission

MP Nusbaum, DM Blitz, E Marder - Nature Reviews Neuroscience, 2017‏ - nature.com
Colocalization of small-molecule and neuropeptide transmitters is common throughout the
nervous system of all animals. The resulting co-transmission, which provides conjoint …

Relevance of interactions between dopamine and glutamate neurotransmission in schizophrenia

SA Buck, M Quincy Erickson-Oberg, RW Logan… - Molecular …, 2022‏ - nature.com
Dopamine (DA) and glutamate neurotransmission are strongly implicated in schizophrenia
pathophysiology. While most studies focus on contributions of neurons that release only DA …

D1 receptor-expressing neurons in ventral tegmental area alleviate mouse anxiety-like behaviors via glutamatergic projection to lateral septum

Q Tong, X Cui, H Xu, X Zhang, S Hu, F Huang… - Molecular …, 2023‏ - nature.com
Dopamine (DA) acts as a key regulator in controlling emotion, and dysfunction of DA signal
has been implicated in the pathophysiology of some psychiatric disorders, including anxiety …

Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement

JH Yoo, V Zell, N Gutierrez-Reed, J Wu… - Nature …, 2016‏ - nature.com
In addition to dopamine neurons, the ventral tegmental area (VTA) contains GABA-,
glutamate-and co-releasing neurons, and recent reports suggest a complex role for the …