Activated B cells participate in either extrafollicular (EF) or germinal center (GC) responses.
Canonical responses are composed of a short wave of plasmablasts (PBs) arising from EF …

Malaria, caused by infection with Plasmodium parasites, drives multiple regulatory
responses across the immune landscape. These regulatory responses help to protect …

Temporal resolution of cellular features associated with a severe COVID-19 disease
trajectory is needed for understanding skewed immune responses and defining predictors of …

Severe forms of malaria are associated with systemic inflammation and host metabolism
disorders; however, the interplay between these outcomes is poorly understood. Using a …

Over 75% of malaria-attributable deaths occur in children under the age of 5 years.
However, the first malaria vaccine recommended by the World Health Organization (WHO) …

The longevity of plasma cells is dependent on their ability to access and reside in so-called
niches that are predominantly located in the bone marrow. Here, by employing a traceable …

In contrast to a second dose of the SARS-CoV-2 mRNA vaccine, a third dose elicits potent
neutralizing activity against the Omicron variant. To address the underlying mechanism for …

Plasmodium falciparum malaria drives immunoregulatory responses across multiple cell
subsets, which protects from immunopathogenesis, but also hampers the development of …

Malaria remains a significant contributor to the global burden of disease, with around 40% of
the world's population at risk of Plasmodium infections. The development of an effective …

Cell fate decisions during early B cell activation determine the outcome of responses to
pathogens and vaccines. We examined the early B cell response to T-dependent antigen in …