Label-free microfluidic cell sorting and detection for rapid blood analysis

N Lu, HM Tay, C Petchakup, L He, L Gong, KK Maw… - Lab on a Chip, 2023 - pubs.rsc.org
Blood tests are considered as standard clinical procedures to screen for markers of diseases
and health conditions. However, the complex cellular background (> 99.9% RBCs) and …

Atomic force microscopy-based force spectroscopy and multiparametric imaging of biomolecular and cellular systems

DJ Müller, AC Dumitru, C Lo Giudice… - Chemical …, 2020 - ACS Publications
During the last three decades, a series of key technological improvements turned atomic
force microscopy (AFM) into a nanoscopic laboratory to directly observe and chemically …

Mechanical adaptability of tumor cells in metastasis

V Gensbittel, M Kräter, S Harlepp, I Busnelli, J Guck… - Developmental cell, 2021 - cell.com
The most dangerous aspect of cancer lies in metastatic progression. Tumor cells will
successfully form life-threatening metastases when they undergo sequential steps along a …

Single-cell microfluidic impedance cytometry: From raw signals to cell phenotypes using data analytics

C Honrado, P Bisegna, NS Swami, F Caselli - Lab on a Chip, 2021 - pubs.rsc.org
The biophysical analysis of single-cells by microfluidic impedance cytometry is emerging as
a label-free and high-throughput means to stratify the heterogeneity of cellular systems …

The extracellular matrix viscoelasticity as a regulator of cell and tissue dynamics

A Elosegui-Artola - Current opinion in cell biology, 2021 - Elsevier
The extracellular matrix mechanical properties regulate processes in development, cancer,
and fibrosis. Among the distinct mechanical properties, the vast majority of research has …

Microfluidic technologies for cell deformability cytometry

H Chen, J Guo, F Bian, Y Zhao - Smart Medicine, 2022 - Wiley Online Library
Microfluidic detection methods for cell deformability cytometry have been regarded as
powerful tools for single‐cell analysis of cellular mechanical phenotypes, thus having been …

Computer vision meets microfluidics: a label-free method for high-throughput cell analysis

S Zhou, B Chen, ES Fu, H Yan - Microsystems & Nanoengineering, 2023 - nature.com
In this paper, we review the integration of microfluidic chips and computer vision, which has
great potential to advance research in the life sciences and biology, particularly in the …

Mechanical properties of single cells: Measurement methods and applications

Y Hao, S Cheng, Y Tanaka, Y Hosokawa… - Biotechnology …, 2020 - Elsevier
Cell mechanical properties, eg elastic and shear modulus, play vital roles in cell activities
and functions, such as cell growth, cell division, cell motion, and cell adhesion …

Impedance‐Based Multimodal Electrical‐Mechanical Intrinsic Flow Cytometry

Y Feng, J Zhu, H Chai, W He, L Huang, W Wang - Small, 2023 - Wiley Online Library
Reflecting various physiological states and phenotypes of single cells, intrinsic biophysical
characteristics (eg, mechanical and electrical properties) are reliable and important, label …

Viscoelastic properties of suspended cells measured with shear flow deformation cytometry

R Gerum, E Mirzahossein, M Eroles, J Elsterer… - Elife, 2022 - elifesciences.org
Numerous cell functions are accompanied by phenotypic changes in viscoelastic properties,
and measuring them can help elucidate higher level cellular functions in health and disease …