FA (fatty acid) synthesis represents a central, conserved process by which acyl chains are
produced for utilization in a number of end-products such as biological membranes. Central …

De novo biosynthesis of fatty acids is an iterative process requiring strict regulation of the
lengths of the produced fatty acids. In this review, we focus on the factors determining chain …

Penicillium chrysogenum (renamed P. rubens) is the most studied member of a family of
more than 350 Penicillium species that constitute the genus. Since the discovery of penicillin …

Covering: 2007 to 2011. Previous review: Nat. Prod. Rep., 2007, 24, 750 Common to all
FASs, PKSs and NRPSs is a remarkable component, the acyl or peptidyl carrier protein …

Covering: up to the end of 2008 Nonribosomal peptides have a variety of medicinal activities
including activity as antibiotics, antitumor drugs, immunosuppressives, and toxins. Their …

A new fumonisin, fumonisin B6 (1), has been isolated by cation-exchange and reverse-
phase chromatography, together with fumonisin B2 (2), from stationary cultures of the fungus …

Fungi possess an advanced secondary metabolism that is regulated and coordinated in a
complex manner depending on environmental challenges. To understand this complexity, a …

Fatty acid synthases (FASs) and polyketide synthases (PKSs) iteratively elongate and often
reduce two-carbon ketide units in de novo fatty acid and polyketide biosynthesis. Cycles of …

Assigning functions to newly discovered genes constitutes one of the major challenges en
route to fully exploiting the data becoming available from the genome sequencing initiatives …

Fatty acid biosynthesis is essential to life and represents one of the most conserved
pathways in nature, preserving the same handful of chemical reactions across all species …