Toward Mechanistic Understanding of Mechanochemical Reactions Using Real-Time In Situ Monitoring

S Lukin, LS Germann, T Friščić… - Accounts of chemical …, 2022 - ACS Publications
Conspectus The past two decades have witnessed a rapid emergence of interest in
mechanochemistry–chemical and materials reactivity achieved or sustained by the action of …

Direct mechanocatalysis: using milling balls as catalysts

W Pickhardt, S Grätz, L Borchardt - Chemistry–A European …, 2020 - Wiley Online Library
Direct mechanocatalysis describes catalytic reactions under the involvement of mechanical
energy with the distinct feature of milling equipment itself being the catalyst. This novel type …

Tackling solubility issues in organic synthesis: solid-state cross-coupling of insoluble aryl halides

T Seo - Palladium-Catalyzed Mechanochemical Cross …, 2024 - Springer
Conventional organic synthesis generally relies on the use of liquid organic solvents to
dissolve the reactants. Therefore, reactions of sparingly soluble or insoluble substrates are …

Raman spectroscopy for real-time and in situ monitoring of mechanochemical milling reactions

S Lukin, K Užarević, I Halasz - Nature Protocols, 2021 - nature.com
Solid-state milling has emerged as an alternative, sustainable approach for preparing
virtually all classes of compounds and materials. In situ reaction monitoring is essential to …

Methods for monitoring milling reactions and mechanistic studies of mechanochemistry: a primer

PA Julien, T Friščić - Crystal Growth & Design, 2022 - ACS Publications
Mechanochemistry by ball milling is garnering significant attention as an efficient and
versatile means of chemical synthesis which minimizes the need for solvents and reduces …

Illuminating milling mechanochemistry by tandem real-time fluorescence emission and Raman spectroscopy monitoring

PA Julien, M Arhangelskis, LS Germann, M Etter… - Chemical …, 2023 - pubs.rsc.org
In pursuit of accessible and interpretable methods for direct and real-time observation of
mechanochemical reactions, we demonstrate a tandem spectroscopic method for monitoring …

Cocrystal Formation Precedes the Mechanochemically Acetate‐Assisted C−H Activation with [Cp*RhCl2]2

KJ Ardila‐Fierro, M Rubčić… - Chemistry–A European …, 2022 - Wiley Online Library
This work reports the experimentally studied mechanochemical formation of rhodacycles by
ball milling pyridine‐and quinoline‐derived substrates and [Cp* RhCl2] 2 in the presence of …

Mechanochemical Pd (II)-catalyzed direct and C-2-selective arylation of indoles

D Das, ZT Bhutia, A Chatterjee… - The Journal of Organic …, 2019 - ACS Publications
A mechanochemical method for the preparation of synthetically useful 2-arylindoles is
developed using Pd (II) as the catalyst in the absence of phosphine ligands in a ball-mill …

The Role of Crystalline Intermediates in Mechanochemical Cyclorhodation Reactions Elucidated by in‐Situ X‐ray Powder Diffraction and Computation

JG Hernández, KJ Ardila‐Fierro… - … A European Journal, 2023 - Wiley Online Library
The occurrence of crystalline intermediates in mechanochemical reactions might be more
widespread than previously assumed. For example, a recent study involving the acetate …

Optical time-lapsed in situ mechanochemical studies on metal halide perovskite systems

Y **ao, DG Bradley, WX Chan, X Hu, L **ao… - Nature …, 2025 - nature.com
Metal halide perovskites are attractive for optoelectronic applications, but the existing
solution-based synthetic methods rely on hazardous solvents and lack reproducibility. To …