Voltage-gated ion channels (VGICs), including those for Na+, Ca2+ and K+, selectively
permeate ions across the cell membrane in response to changes in membrane potential …

▪ Abstract The cell membrane Na, K-ATPase is a member of the P-type family of active cation
transport proteins. Recently the molecular structure of the related sarcoplasmic reticulum Ca …

An essential protein of the SARS-CoV-2 virus, the envelope protein E, forms a
homopentameric cation channel that is important for virus pathogenicity. Here we report a …

Harvesting energy from the environment offers the promise of clean power for self-sustained
systems,. Known technologies—such as solar cells, thermoelectric devices and mechanical …

The potassium channel from Streptomyces lividans is an integral membrane protein with
sequence similarity to all known K+ channels, particularly in the pore region. X-ray analysis …

Transient receptor potential (TRP) channels are sensors for a wide range of cellular and
environmental signals, but elucidating how these channels respond to physical and …

Most general anaesthetics and classical benzodiazepine drugs act through positive
modulation of γ-aminobutyric acid type A (GABAA) receptors to dampen neuronal activity in …

Type-A γ-aminobutyric (GABAA) receptors are ligand-gated chloride channels with a very
rich pharmacology. Some of their modulators, including benzodiazepines and general …

Olfactory systems must detect and discriminate amongst an enormous variety of odorants.
To contend with this challenge, diverse species have converged on a common strategy in …

Transient receptor potential (TRP) channels are polymodal signal detectors that respond to
a wide range of physical and chemical stimuli. Elucidating how these channels integrate and …