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Harnessing innate immune pathways for therapeutic advancement in cancer
The innate immune pathway is receiving increasing attention in cancer therapy. This
pathway is ubiquitous across various cell types, not only in innate immune cells but also in …
pathway is ubiquitous across various cell types, not only in innate immune cells but also in …
Exploiting RIG-I-like receptor pathway for cancer immunotherapy
Y Jiang, H Zhang, J Wang, J Chen, Z Guo, Y Liu… - Journal of Hematology & …, 2023 - Springer
RIG-I-like receptors (RLRs) are intracellular pattern recognition receptors that detect viral or
bacterial infection and induce host innate immune responses. The RLRs family comprises …
bacterial infection and induce host innate immune responses. The RLRs family comprises …
Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma
Y Zhou, D Yang, Q Yang, X Lv, W Huang… - Nature …, 2020 - nature.com
Osteosarcoma is the most frequent primary bone tumor with poor prognosis. Through RNA-
sequencing of 100,987 individual cells from 7 primary, 2 recurrent, and 2 lung metastatic …
sequencing of 100,987 individual cells from 7 primary, 2 recurrent, and 2 lung metastatic …
TIGIT, a novel immune checkpoint therapy for melanoma
W Tang, J Chen, T Ji, X Cong - Cell Death & Disease, 2023 - nature.com
Melanoma is the most aggressive and deadliest type of skin cancer. In the last 10 years,
immune checkpoint blockades (ICBs) including PD-1/PD-L1 and CTLA-4 inhibitor has been …
immune checkpoint blockades (ICBs) including PD-1/PD-L1 and CTLA-4 inhibitor has been …
Therapeutically increasing MHC-I expression potentiates immune checkpoint blockade
Immune checkpoint blockade (ICB) therapy revolutionized cancer treatment, but many
patients with impaired MHC-I expression remain refractory. Here, we combined FACS-based …
patients with impaired MHC-I expression remain refractory. Here, we combined FACS-based …
Physiological functions of RIG-I-like receptors
M Yoneyama, H Kato, T Fujita - Immunity, 2024 - cell.com
RIG-I-like receptors (RLRs) are crucial for pathogen detection and triggering immune
responses and have immense physiological importance. In this review, we first summarize …
responses and have immense physiological importance. In this review, we first summarize …
The m6A Reader YTHDF2 Promotes Bladder Cancer Progression by Suppressing RIG-I–Mediated Immune Response
L Zhang, Y Li, L Zhou, H Zhou, L Ye, T Ou… - Cancer …, 2023 - aacrjournals.org
Abstract N6-Methyladenosine (m6A) is the most prevalent internal modification of
mammalian mRNAs. Recent studies have shown that m6A methyltransferases METTL3 and …
mammalian mRNAs. Recent studies have shown that m6A methyltransferases METTL3 and …
Cancer immunotherapies: from efficacy to resistance mechanisms–not only checkpoint matters
S Wang, K ** the immune landscape in metastatic melanoma reveals localized cell–cell interactions that predict immunotherapy response
While immune checkpoint–based immunotherapy (ICI) shows promising clinical results in
patients with cancer, only a subset of patients responds favorably. Response to ICI is …
patients with cancer, only a subset of patients responds favorably. Response to ICI is …