Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …

Following the discovery of nucleic acids by Friedrich Miescher in 1868, DNA and RNA were
recognized as the genetic code containing the necessary information for proper cell …

Clusterin (CLU) or APOJ is a multifunctional glycoprotein that has been implicated in several
physiological and pathological states, including Alzheimer's disease (AD). With a prominent …

Dramatic advances in understanding of the roles RNA plays in normal health and disease
have greatly expanded over the past 10 years and have made it clear that scientists are only …

Simple Summary Nucleic acid drugs provide novel therapeutic modalities with
characteristics that differ from those of small molecules and antibodies. In this review, I focus …

SUMMARY 1 An antisense oligonucleotide (ASO) is a short strand of deoxyribonucleotide
analogue that hybridizes with the complementary mRNA in a sequence‐specific manner via …

Peptide-oligonucleotide conjugates (POCs) represent one of the increasingly successful
albeit costly approaches to increasing the cellular uptake, tissue delivery, bioavailability …

A series of antisense oligonucleotides (ASOs) containing either 2′-O-methoxyethylribose
(MOE) or locked nucleic acid (LNA) modifications were designed to investigate whether LNA …

Previous in vivo studies have suggested that nucleic acid polymers (NAPs) may reduce
circulating levels of HBsAg in the blood by blocking its release from infected hepatocytes …

The role of apolipoproteins in cardiovascular disease has been well investigated, but their
participation in cancer has only been explored in a few published studies which showed a …