Bacterial infections following influenza are an important cause of morbidity and mortality
worldwide. Based on the historical importance of pneumonia as a cause of death during …

Animal models remain invaluable for study of respiratory diseases, however, translation of
data generated in genetically homogeneous animals housed in a clean and well-controlled …

Cytokine storm during viral infection is a prospective predictor of morbidity and mortality, yet
the cellular sources remain undefined. Here, using genetic and chemical tools to probe …

Microbial colonization of mucosal surfaces may be an initial event in the progression to
disease, and it is often a transient process. For the extracellular pathogen Streptococcus …

Pneumolysin (PLY) is a key Streptococcus pneumoniae virulence factor and potential
candidate for inclusion in pneumococcal subunit vaccines. Dendritic cells (DC) play a key …

During pathogenic influenza virus infection, robust cytokine production (cytokine storm),
excessive inflammatory infiltrates, and virus-induced tissue destruction all contribute to …

Human pandemic H1N1 2009 influenza virus rapidly infected millions worldwide and was
associated with significant mortality. Antiviral drugs that inhibit influenza virus replication are …

Galectin-3 is a member of the galectin family, widely expressed in immune cells and plays a
role mainly in inflammation, autoimmunity, apoptosis, and chemotaxis. We summarized the …

Recruitment of neutrophils from blood vessels to sites of infection represents one of the most
important elements of innate immunity. Movement of neutrophils across blood vessel walls …

Sodium absorption by an amiloride-sensitive channel is the main driving force of lung liquid
clearance at birth and lung edema clearance in adulthood. In this study, we tested whether …