Freeze tolerance is an amazing winter survival strategy used by various amphibians and
reptiles living in seasonally cold environments. These animals may spend weeks or months …

Many vertebrates are challenged by either chronic or acute episodes of low oxygen
availability in their natural environments. Brain function is especially vulnerable to the effects …

For many animals, survival of severe environmental stress (eg to extremes of heat or cold,
drought, oxygen limitation, food deprivation) is aided by entry into a hypometabolic state …

While mammals cannot survive oxygen deprivation for more than a few minutes without
sustaining severe organ damage, some animals have mastered anaerobic life. Freshwater …

Epigenetic regulation, notably histone post-translational modification (PTM), has emerged
as a major transcriptional control of gene expression during cellular stress adaptation. In the …

Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in
histone and nonhistone proteins and in regulating fundamental cellular activities. In this …

Organisms respond to severe environmental changes by entering into hypometabolic states,
minimizing their metabolic rates, suspending development and reproduction, and surviving …

The jumbo squid, Dosidicus gigas, can survive extended forays into the oxygen minimum
zone (OMZ) of the Eastern Pacific Ocean. Previous studies have demonstrated reduced …

Background While oxygen limitation can be extremely damaging for many animals, some
vertebrates have perfected anaerobic survival. Freshwater turtles belonging to the …

Hibernating mammals employ strong metabolic rate depression to survive the winter,
thereby avoiding the high energy costs of maintaining a euthermic lifestyle in the face of low …