Severe covid-19 pneumonia has posed critical challenges for the research and medical
communities. Older age, male sex, and comorbidities increase the risk for severe disease …

Delirium is the most common manifestation of brain dysfunction in critically ill patients. In the
intensive care unit (ICU), duration of delirium is independently predictive of excess death …

Background Intensive care unit (ICU)–acquired weakness often develops in patients who
are undergoing invasive mechanical ventilation. Early active mobilization may mitigate ICU …

Background: This document updates previously published Clinical Practice Guidelines for
the management of patients with acute respiratory distress syndrome (ARDS), incorporating …

OBJECTIVE: To develop comprehensive clinical practice guidelines for critically ill infants
and children, with specific attention to seven domains of care including pain …

Background Patients who have received mechanical ventilation can have prolonged
cognitive impairment for which there is no known treatment. We aimed to establish whether …

Delirium, a syndrome characterized by an acute change in attention, awareness and
cognition, is caused by a medical condition that cannot be better explained by a pre-existing …

Background Haloperidol is frequently used to treat delirium in patients in the intensive care
unit (ICU), but evidence of its effect is limited. Methods In this multicenter, blinded, placebo …

Objective Covid‐19 can involve multiple organs including the nervous system. We sought to
characterize the neurologic manifestations, their risk factors, and associated outcomes in …

Background To date, 750 000 patients with COVID-19 worldwide have required mechanical
ventilation and thus are at high risk of acute brain dysfunction (coma and delirium). We …