Background Intracellular DNA-sensing pathway cGAS-STING, inflammasomes and
pyroptosis act as critical natural immune signaling axes for microbial infection, chronic …

The NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome pathway is
mainly responsible for the activation and release of a cascade of proinflammatory mediators …

There has been increasing interest in pyroptosis as a novel form of pro-inflammatory
programmed cell death. The mechanism of pyroptosis is significantly different from other …

The liver is an essential immunological organ due to its gatekeeper position to bypassing
antigens from the intestinal blood flow and microbial products from the intestinal …

Inflammasomes have emerged as critical innate sensors of host immune that defense
against pathogen infection, metabolism syndrome, cellular stress and cancer metastasis in …

Procyanidins, as a kind of dietary flavonoid, have excellent pharmacological properties,
such as antioxidant, antibacterial, anti-inflammatory and anti-tumor properties, and so they …

Inflammasomes, particularly the nucleotide-binding oligomerization domain, leucine-rich
repeat, and pyrin domain containing 3 (NLRP3) inflammasome, apparently serve as crucial …

The Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome has been
the most distinctive polymer protein complex. After recognizing the endogenous and …

Inflammation is a hallmark of progressive liver diseases such as chronic viral or immune-
mediated hepatitis, alcohol-associated liver disease, and NAFLD. Preclinical and clinical …

Hepatitis B virus (HBV) infection is a worldwide medical issue with significant morbidity and
mortality, as it is the main cause of chronic liver disease and hepatocellular carcinoma …