Myocardial ischaemia–reperfusion injury and cardioprotection in perspective
G Heusch - Nature Reviews Cardiology, 2020 - nature.com
Despite the increasing use and success of interventional coronary reperfusion strategies,
morbidity and mortality from acute myocardial infarction are still substantial. Myocardial …
morbidity and mortality from acute myocardial infarction are still substantial. Myocardial …
Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury: JACC Review Topic of the Week
Many treatments have been identified that confer robust cardioprotection in experimental
animal models of acute ischemia and reperfusion injury. However, translation of these …
animal models of acute ischemia and reperfusion injury. However, translation of these …
[HTML][HTML] Dexmedetomidine attenuates myocardial ischemia/reperfusion-induced ferroptosis via AMPK/GSK-3β/Nrf2 axis
Z Wang, M Yao, L Jiang, L Wang, Y Yang… - Biomedicine & …, 2022 - Elsevier
The present study aimed to investigate whether dexmedetomidine (Dex) exerts
cardioprotection effect through inhibiting ferroptosis. Myocardial ischemia/reperfusion injury …
cardioprotection effect through inhibiting ferroptosis. Myocardial ischemia/reperfusion injury …
Guidelines for experimental models of myocardial ischemia and infarction
Myocardial infarction is a prevalent major cardiovascular event that arises from myocardial
ischemia with or without reperfusion, and basic and translational research is needed to …
ischemia with or without reperfusion, and basic and translational research is needed to …
Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection
The potential for ischemic preconditioning to reduce infarct size was first recognized more
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …
Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European …
Extracellular vesicles (EVs)—particularly exosomes and microvesicles (MVs)—are attracting
considerable interest in the cardiovascular field as the wide range of their functions is …
considerable interest in the cardiovascular field as the wide range of their functions is …
Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study …
D Montaigne, X Marechal, T Modine, A Coisne… - The Lancet, 2018 - thelancet.com
Background On-pump cardiac surgery provokes a predictable perioperative myocardial
ischaemia–reperfusion injury which is associated with poor clinical outcomes. We …
ischaemia–reperfusion injury which is associated with poor clinical outcomes. We …
[HTML][HTML] European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …
The coronary circulation in acute myocardial ischaemia/reperfusion injury: a target for cardioprotection
The coronary circulation is both culprit and victim of acute myocardial infarction. The rupture
of an epicardial atherosclerotic plaque with superimposed thrombosis causes coronary …
of an epicardial atherosclerotic plaque with superimposed thrombosis causes coronary …
[HTML][HTML] Inflammation following acute myocardial infarction: multiple players, dynamic roles, and novel therapeutic opportunities
Acute myocardial infarction (AMI) and the heart failure that often follows, are major causes of
death and disability worldwide. As such, new therapies are required to limit myocardial …
death and disability worldwide. As such, new therapies are required to limit myocardial …