Next-generation sequencing: insights to advance clinical investigations of the microbiome
Next-generation sequencing (NGS) technology has advanced our understanding of the
human microbiome by allowing for the discovery and characterization of unculturable …
human microbiome by allowing for the discovery and characterization of unculturable …
Microbiota succession throughout life from the cradle to the grave
Associations between age and the human microbiota are robust and reproducible. The
microbial composition at several body sites can predict human chronological age relatively …
microbial composition at several body sites can predict human chronological age relatively …
SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection
P Feuerstadt, TJ Louie, B Lashner… - … England Journal of …, 2022 - Mass Medical Soc
Background Current therapies for recurrent Clostridioides difficile infection do not address
the disrupted microbiome, which supports C. difficile spore germination into toxin-producing …
the disrupted microbiome, which supports C. difficile spore germination into toxin-producing …
Efficacy and safety of RBX2660 in PUNCH CD3, a phase III, randomized, double-blind, placebo-controlled trial with a Bayesian primary analysis for the prevention of …
Abstract Background Recurrent Clostridioides difficile infection, associated with dysbiosis of
gut microbiota, has substantial disease burden in the USA. RBX2660 is a live biotherapeutic …
gut microbiota, has substantial disease burden in the USA. RBX2660 is a live biotherapeutic …
ECCO guidelines on the prevention, diagnosis, and management of infections in inflammatory bowel disease
T Kucharzik, P Ellul, T Greuter, JF Rahier… - Journal of Crohn's …, 2021 - academic.oup.com
The introduction and broad use of new immunosuppressive agents, including biologic
agents and JAK inhibitors, have revolutionised treatment of inflammatory bowel disease …
agents and JAK inhibitors, have revolutionised treatment of inflammatory bowel disease …
Gut microbiota influence in type 2 diabetes mellitus (T2DM)
A strong and expanding evidence base supports the influence of gut microbiota in human
metabolism. Altered glucose homeostasis is associated with altered gut microbiota, and is …
metabolism. Altered glucose homeostasis is associated with altered gut microbiota, and is …
Problems with the concept of gut microbiota dysbiosis
H Brüssow - Microbial biotechnology, 2020 - Wiley Online Library
The human microbiome research is with the notable exception of fecal transplantation still
mostly in a descriptive phase. Part of the difficulty for translating research into medical …
mostly in a descriptive phase. Part of the difficulty for translating research into medical …
Faecal microbiota transplantation for Clostridioides difficile: mechanisms and pharmacology
Faecal microbiota transplantation (FMT) has emerged as a remarkably successful treatment
for recurrent Clostridioides difficile infection that cannot be cured with antibiotics alone …
for recurrent Clostridioides difficile infection that cannot be cured with antibiotics alone …
Durable reduction of Clostridioides difficile infection recurrence and microbiome restoration after treatment with RBX2660: results from an open-label phase 2 clinical …
Background Effective treatment options for recurrent Clostridioides difficile infection (rCDI)
are limited, with high recurrence rates associated with the current standard of care. Herein …
are limited, with high recurrence rates associated with the current standard of care. Herein …
Probiotics, prebiotics, synbiotics, and fecal microbiota transplantation in the treatment of behavioral symptoms of autism spectrum disorder: A systematic review
The emerging role of a microbiota‐gut‐brain axis in autism spectrum disorder (ASD)
suggests that modulating gut microbial composition may offer a tractable approach to …
suggests that modulating gut microbial composition may offer a tractable approach to …