Autoimmune diseases are caused when immune cells act against self-protein. This
biological self–non-self-discrimination phenomenon is controlled by a distinct group of …

Abstract The T helper 17 (Th17) cells contain a dynamic subset of CD4+ T-cells that are able
to develop into other different lineage subsets, including the Th1-like Th17 cells. These cells …

Autoimmune disease, caused by unwanted immune responses to self-antigens, affects
millions of people each year and poses a great social and economic burden to individuals …

Forkhead box P3–expressing regulatory T (Treg) cells are essential for self-tolerance, with
an emerging role in tissue repair and regeneration. Their ability to traffic to tissue and …

Biomarkers may have a diagnostic or monitoring value, or may predict response to therapy
or disease course. The aim of this review is to discuss new serum and urinary biomarkers …

Abstract Interleukin-2 (IL-2) is a pleiotropic cytokine required for both effector lymphocyte
proliferation/differentiation and regulatory T cell expansion/survival. Ability to receive IL-2 …

Regulatory T cells (Tregs) are central in integration and maintenance of immune
homeostasis. Since breakdown of self-tolerance is a major culprit in the pathogenesis of …

CCR6 is a G protein-coupled receptor (GPCR) that binds to a specific chemokine, CCL20.
The role of CCR6-CCL20 is very well studied in the migration of immune cells, but the non …

Highlights•IL-2 shortage is a hallmark of SLE.•rIL-2 supplementation therapies show
promising clinical benefits.•rIL-2 boosts Treg cells in SLE patients.•IL-2 is a negative …

Background: At present intraocular pressure (IOP) lowering therapies are the only approach
to treat glaucoma. Neuroprotective strategies to protect the retinal ganglion cells (RGC) from …