Parkinson's disease (PD) is the second most prevalent neurological disorder and has been
the focus of intense investigations to understand its etiology and progression, but it still lacks …

Background Alzheimer's disease (AD) is an insidious, irreversible, and progressive
neurodegenerative health condition manifesting as cognitive deficits and amyloid beta (Aβ) …

Modeling Parkinson's disease (PD) using advanced experimental in vitro models is a
powerful tool to study disease mechanisms and to elucidate unexplored aspects of this …

The CRISPR/Cas system, an innovative gene-editing tool, is emerging as a promising
technique for genome modifications. This straightforward technique was created based on …

Abstract Parkinson's disease (PD)‐specific neurons, grown in standard 2D cultures, typically
only display weak endophenotypes. The cultivation of PD patient‐specific neurons, derived …

Since its discovery in 2012, CRISPR Cas9 has been tried as a direct treatment approach to
correct the causative gene mutation and establish animal models in neurodegenerative …

Human brain organoid models that recapitulate the physiology and complexity of the human
brain have a great potential for in vitro disease modeling, in particular for neurodegenerative …

The etiology of many neurological diseases affecting the central nervous system (CNS) is
unknown and still needs more effective and specific therapeutic approaches. Gene therapy …

Parkinson's disease (PD) and other chronic and debilitating neurodegenerative diseases
(NDs) impose a substantial medical, emotional, and financial burden on individuals and …

Mutations in specific genes, including synuclein alpha (SNCA) that encodes the α-synuclein
protein, are known to be risk factors for sporadic Parkinson's disease (PD), as well as critical …