The matrix environmental and cell mechanical properties regulate cell migration and contribute to the invasive phenotype of cancer cells
CT Mierke - Reports on Progress in Physics, 2019 - iopscience.iop.org
The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
[HTML][HTML] Phagocytosis by the retinal pigment epithelium: recognition, resolution, recycling
W Kwon, SA Freeman - Frontiers in immunology, 2020 - frontiersin.org
Tissue-resident phagocytes are responsible for the routine binding, engulfment, and
resolution of their meals. Such populations of cells express appropriate surface receptors …
resolution of their meals. Such populations of cells express appropriate surface receptors …
The filamins: organizers of cell structure and function
F Nakamura, TP Stossel, JH Hartwig - Cell adhesion & migration, 2011 - Taylor & Francis
Filamin A (FLNa), the first non-muscle actin filament cross-linking protein, was identified in
1975. Thirty five years of FLNa research has revealed its structure in great detail, discovered …
1975. Thirty five years of FLNa research has revealed its structure in great detail, discovered …
Force feedback controls motor activity and mechanical properties of self-assembling branched actin networks
Branched actin networks—created by the Arp2/3 complex, cap** protein, and a nucleation
promoting factor—generate and transmit forces required for many cellular processes, but …
promoting factor—generate and transmit forces required for many cellular processes, but …
Molecular mechanisms of cellular mechanosensing
Mechanical forces direct a host of cellular and tissue processes. Although much emphasis
has been placed on cell-adhesion complexes as force sensors, the forces must nevertheless …
has been placed on cell-adhesion complexes as force sensors, the forces must nevertheless …
An active biopolymer network controlled by molecular motors
We describe an active polymer network in which processive molecular motors control
network elasticity. This system consists of actin filaments cross-linked by filamin A (FLNa) …
network elasticity. This system consists of actin filaments cross-linked by filamin A (FLNa) …
Vinculin controls talin engagement with the actomyosin machinery
P Atherton, B Stutchbury, DY Wang, D Jethwa… - Nature …, 2015 - nature.com
The link between extracellular-matrix-bound integrins and intracellular F-actin is essential
for cell spreading and migration. Here, we demonstrate how the actin-binding proteins talin …
for cell spreading and migration. Here, we demonstrate how the actin-binding proteins talin …
Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A
Mechanical stresses elicit cellular reactions mediated by chemical signals. Defective
responses to forces underlie human medical disorders,,, such as cardiac failure and …
responses to forces underlie human medical disorders,,, such as cardiac failure and …
Decorin interacting network: a comprehensive analysis of decorin-binding partners and their versatile functions
Decorin, a prototype small leucine-rich proteoglycan, regulates a vast array of cellular
processes including collagen fibrillogenesis, wound repair, angiostasis, tumor growth, and …
processes including collagen fibrillogenesis, wound repair, angiostasis, tumor growth, and …
ULK phosphorylation of STX17 controls autophagosome maturation via FLNA
Y Wang, H Que, CP Li, Z Wu, F Jian, Y Zhao… - Journal of Cell …, 2023 - rupress.org
Autophagy is a conserved and tightly regulated intracellular quality control pathway. ULK is
a key kinase in autophagy initiation, but whether ULK kinase activity also participates in the …
a key kinase in autophagy initiation, but whether ULK kinase activity also participates in the …