Skeletal muscle contains a designated population of adult stem cells, called satellite cells,
which are generally quiescent. In homeostasis, satellite cells proliferate only sporadically …

While the elderly segment of the population continues growing in importance,
neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition …

Skeletal muscle regeneration depends on the correct expansion of resident quiescent stem
cells (satellite cells), a process that becomes less efficient with aging. Here, we show that …

Extracellular matrix stiffening is a quintessential feature of cartilage aging, a leading cause
of knee osteoarthritis. Yet, the downstream molecular and cellular consequences of age …

The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

Skeletal muscle regeneration is a finely tuned process involving the activation of various
cellular and molecular processes. Satellite cells, the stem cells of skeletal muscle, are …

Heterochronic blood exchange (HBE) has demonstrated that circulating factors restore
youthful features to aged tissues. However, the systemic mediators of those rejuvenating …

Given the rapidly aging population, aging-related diseases are becoming an excessive
burden on the global healthcare system. Metformin has been shown to be beneficial to many …

Reducing oxidative stress stands at the center of a prevention and control strategy for
mitigating cellular senescence and aging. Kidney disease is characterized by a premature …

The characteristic maximum lifespan varies enormously across animal species from a few
hours to hundreds of years. This argues that maximum lifespan, and the ageing process that …