Neuroblastoma is a tumour derived from primitive cells of the sympathetic nervous system
and is the most common solid tumour in childhood. Interestingly, most infants experience …

Neuroblastoma is a solid tumour that arises from the develo** sympathetic nervous
system. Over the past decade, our understanding of this disease has advanced …

Acclaimed by the worldwide medical community as" a staple reference text in the medical
oncologist's library"(JAMA), DeVita, Hellman, and Rosenberg's Cancer: Principles and …

Multidrug transporter proteins are best known for their contributions to chemoresistance
through the efflux of anticancer drugs from cancer cells. However, a considerable body of …

A subset of stem cells, termed the “side population”(SP), has been identified in several
tissues in mammalian species. These cells maintain a high efflux capability for antimitotic …

Abstract c-myc, N-myc and L-myc are the three members of the myc oncoprotein family
whose role in the pathogenesis of many human neoplastic diseases has received wide …

Multidrug Resistance Proteins (MRPs), together with the cystic fibrosis conductance
regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) …

Neuroblastoma, a neoplasm of the sympathetic nervous system, is the second most common
extracranial malignant tumor of childhood and the most common solid tumor of infancy …

Resistance to chemotherapy remains one of the most significant obstacles to successful
cancer treatment. While inhibiting drug efflux mediated by ATP-binding cassette (ABC) …

PURPOSE AND RESULTS: Neuroblastoma, the most common solid extracranial neoplasm
in children, is remarkable for its clinical heterogeneity. Complex patterns of genetic …