d-Galactose-induced accelerated aging model: an overview
To facilitate the process of aging healthily and prevent age-related health problems, efforts
to properly understand aging mechanisms and develop effective and affordable anti-aging …
to properly understand aging mechanisms and develop effective and affordable anti-aging …
[HTML][HTML] Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer's disease
Y Li, J Zhang, J Wan, A Liu, J Sun - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Alzheimer's disease (AD) is an age-related neurodegenerative disease with multiple
predisposing factors and complicated pathogenesis. Aβ peptide is one of the most important …
predisposing factors and complicated pathogenesis. Aβ peptide is one of the most important …
Natural dietary supplementation of anthocyanins via PI3K/Akt/Nrf2/HO-1 pathways mitigate oxidative stress, neurodegeneration, and memory impairment in a mouse …
Well-established studies have shown an elevated level of reactive oxygen species (ROS)
that induces oxidative stress in the Alzheimer's disease (AD) patient's brain and an animal …
that induces oxidative stress in the Alzheimer's disease (AD) patient's brain and an animal …
Nrf2–ARE pathway: an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases
Neurodegenerative diseases (NDDs) are predicted to be the biggest health concern in this
century and the second leading cause of death by 2050. The main risk factor of these …
century and the second leading cause of death by 2050. The main risk factor of these …
Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT 3‐dependent regulation of oxidative stress and apoptosis
M Zhai, B Li, W Duan, L **g, B Zhang… - Journal of pineal …, 2017 - Wiley Online Library
Sirtuins are a family of highly evolutionarily conserved nicotinamide adenine nucleotide‐
dependent histone deacetylases. Sirtuin‐3 (SIRT 3) is a member of the sirtuin family that is …
dependent histone deacetylases. Sirtuin‐3 (SIRT 3) is a member of the sirtuin family that is …
Neuroprotective effect of quercetin against the detrimental effects of LPS in the adult mouse brain
Chronic neuroinflammation is responsible for multiple neurodegenerative diseases, such as
Alzheimer's disease, Parkinson's disease, and Huntington's disease. Lipopolysaccharide …
Alzheimer's disease, Parkinson's disease, and Huntington's disease. Lipopolysaccharide …
Mitochondria: the birth place, battle ground and the site of melatonin metabolism in cells
It was a surprising discovery when mitochondria, as the power houses of cells, were also
found to synthesize the potent mitochondrial targeted antioxidant, melatonin. The melatonin …
found to synthesize the potent mitochondrial targeted antioxidant, melatonin. The melatonin …
Role of D-galactose-induced brain aging and its potential used for therapeutic interventions
Aging is a phenomenon that all living organisms inevitably face. Every year, 9.9 million
people, globally, suffer from dementia, an indicator of the aging brain. Brain aging is …
people, globally, suffer from dementia, an indicator of the aging brain. Brain aging is …
Natural compounds for Alzheimer's disease therapy: a systematic review of preclinical and clinical studies
Alzheimer's Disease (AD) is a neurodegenerative disorder related with the increase of age
and it is the main cause of dementia in the world. AD affects cognitive functions, such as …
and it is the main cause of dementia in the world. AD affects cognitive functions, such as …
Anthocyanins reversed D-galactose-induced oxidative stress and neuroinflammation mediated cognitive impairment in adult rats
Aging is a major factor involved in neurological impairments, decreased anti-oxidant
activities, and enhanced neuroinflammation. D-galactose (D-gal) has been considered an …
activities, and enhanced neuroinflammation. D-galactose (D-gal) has been considered an …