Abstract RNA-sequencing (RNA-seq) has a wide variety of applications, but no single
analysis pipeline can be used in all cases. We review all of the major steps in RNA-seq data …

Covering: up to 2022 With the emergence of large amounts of omics data, computational
approaches for the identification of plant natural product biosynthetic pathways and their …

Exercise enhances physical performance and reduces the risk of many disorders such as
cardiovascular disease, type 2 diabetes, dementia, and cancer. Exercise characteristically …

Specific microbial signals induce the differentiation of a distinct pool of RORγ+ regulatory T
(Treg) cells crucial for intestinal homeostasis. We discovered highly analogous populations …

Up to 40% of patients with inflammatory bowel disease present with psychosocial
disturbances. We previously identified a gut vascular barrier that controls the dissemination …

The evolution of gene expression in mammalian organ development remains largely
uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum …

Trajectory inference has radically enhanced single-cell RNA-seq research by enabling the
study of dynamic changes in gene expression. Downstream of trajectory inference, it is vital …

Immunotherapy utilizing chimeric antigen receptor T cell (CAR-T) therapy holds promise for
hematologic malignancies, however, response rates and associated immune-related …

Abstract N 6-methyladenosine (m6A) is the most common and abundant messenger RNA
modification, modulated by 'writers','erasers' and 'readers' of this mark,. In vitro data have …

Gut microbes are linked to host metabolism, but specific mechanisms remain to be
uncovered. Ceramides, a type of sphingolipid (SL), have been implicated in the …