Molecular mechanisms linking oxidative stress and diabetes mellitus

H Yaribeygi, T Sathyapalan, SL Atkin… - … medicine and cellular …, 2020 - Wiley Online Library
Type 2 diabetes mellitus (T2DM) is the most prevalent metabolic disorder characterized by
chronic hyperglycemia and an inadequate response to circulatory insulin by peripheral …

Obesity and dyslipidemia

J Vekic, A Zeljkovic, A Stefanovic, Z Jelic-Ivanovic… - Metabolism, 2019 - Elsevier
Obesity, a pandemic of the modern world, is intimately associated with dyslipidemia, which
is mainly driven by the effects of insulin resistance and pro-inflammatory adipokines …

A review of the molecular mechanisms of hyperglycemia‐induced free radical generation leading to oxidative stress

H Yaribeygi, SL Atkin… - Journal of cellular …, 2019 - Wiley Online Library
The prevalence of diabetes is growing worldwide with an increasing morbidity and mortality
associated with the development of diabetes complications. Free radical production is a …

The therapeutic and diagnostic role of exosomes in cardiovascular diseases

P Zamani, N Fereydouni, AE Butler… - Trends in cardiovascular …, 2019 - Elsevier
Exosomes are nano-sized membranous vesicles that are secreted by cells. They have an
important role in transferring proteins, mRNA, miRNA and other bioactive molecules …

Unlocking the full potential of SGLT2 inhibitors: expanding applications beyond glycemic control

ME Youssef, G Yahya, MS Popoviciu, S Cavalu… - International Journal of …, 2023 - mdpi.com
The number of diabetic patients has risen dramatically in recent decades, owing mostly to
the rising incidence of type 2 diabetes mellitus (T2DM). Several oral antidiabetic …

Differential expression of urinary exosomal microRNAs miR-21-5p and miR-30b-5p in individuals with diabetic kidney disease

J Zang, AP Maxwell, DA Simpson, GJ McKay - Scientific Reports, 2019 - nature.com
Biomarkers for the identification of diabetic kidney disease (DKD) are needed as current
tests lack sensitivity for detecting early kidney damage. MicroRNAs (miRNAs) are short, non …

Association between passive smoking and cardiovascular disease: A systematic review and meta‐analysis

M Khoramdad, A Vahedian‐azimi, L Karimi… - IUBMB …, 2020 - Wiley Online Library
Background The association between passive smoking (PS) and cardiovascular disease
(CVD) has not yet been fully clarified. Objective This meta‐analysis was performed to …

Mitochondrial dysfunction in cardiovascular disease: Current status of translational research/clinical and therapeutic implications

AS Manolis, AA Manolis, TA Manolis… - Medicinal Research …, 2021 - Wiley Online Library
Mitochondria provide energy to the cell during aerobic respiration by supplying~ 95% of the
adenosine triphosphate (ATP) molecules via oxidative phosphorylation. These organelles …

Oxidative stress signaling in the pathogenesis of diabetic cardiomyopathy and the potential therapeutic role of antioxidant naringenin

N Xu, S Liu, Y Zhang, Y Chen, Y Zuo, X Tan, B Liao… - Redox …, 2023 - Taylor & Francis
Diabetes mellitus (DM) is one of the most prevalent metabolic disorders that poses a global
threat to human health. It can lead to complications in multiple organs and tissues, owing to …

Molecular mechanisms by which aerobic exercise induces insulin sensitivity

H Yaribeygi, SL Atkin… - Journal of cellular …, 2019 - Wiley Online Library
Insulin resistance is a key feature of Type 2 diabetes and an important therapeutic target to
address glycemic control to prevent diabetic complications. Lifestyle advice is the first step in …