The etiology of preeclampsia

E Jung, R Romero, L Yeo, N Gomez-Lopez… - American journal of …, 2022 - Elsevier
Preeclampsia is one of the “great obstetrical syndromes” in which multiple and sometimes
overlap** pathologic processes activate a common pathway consisting of endothelial cell …

Preeclampsia and eclampsia: the conceptual evolution of a syndrome

O Erez, R Romero, E Jung, P Chaemsaithong… - American journal of …, 2022 - Elsevier
Preeclampsia, one of the most enigmatic complications of pregnancy, is considered a
pregnancy-specific disorder caused by the placenta and cured only by delivery. This article …

Preeclampsia: pathophysiology, challenges, and perspectives

S Rana, E Lemoine, JP Granger… - Circulation …, 2019 - ahajournals.org
Hypertensive disorders of pregnancy—chronic hypertension, gestational hypertension, and
preeclampsia—are uniquely challenging as the pathology and its therapeutic management …

Pre-eclampsia: pathogenesis, novel diagnostics and therapies

EA Phipps, R Thadhani, T Benzing… - Nature Reviews …, 2019 - nature.com
Pre-eclampsia is a complication of pregnancy that is associated with substantial maternal
and fetal morbidity and mortality. The disease presents with new-onset hypertension and …

[HTML][HTML] Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders

S Rana, SD Burke, SA Karumanchi - American journal of obstetrics and …, 2022 - Elsevier
Preeclampsia is a devastating medical complication of pregnancy that can lead to significant
maternal and fetal morbidity and mortality. It is currently believed that there is abnormal …

Preeclampsia: updates in pathogenesis, definitions, and guidelines

E Phipps, D Prasanna, W Brima… - Clinical Journal of the …, 2016 - journals.lww.com
Preeclampsia is becoming an increasingly common diagnosis in the developed world and
remains a high cause of maternal and fetal morbidity and mortality in the develo** world …

[HTML][HTML] Preeclampsia: maternal systemic vascular disorder caused by generalized endothelial dysfunction due to placental antiangiogenic factors

T Tomimatsu, K Mimura, S Matsuzaki, M Endo… - International journal of …, 2019 - mdpi.com
Preeclampsia, a systemic vascular disorder characterized by new-onset hypertension and
proteinuria after 20 weeks of gestation, is the leading cause of maternal and perinatal …

Preeclampsia: pathogenesis, prevention, and long-term complications

B Jim, SA Karumanchi - Seminars in nephrology, 2017 - Elsevier
Preeclampsia continues to afflict 5% to 8% of all pregnancies throughout the world and is
associated with significant morbidity and mortality to the mother and the fetus. Although the …

Preeclampsia: novel mechanisms and potential therapeutic approaches

Z Armaly, JE Jadaon, A Jabbour, ZA Abassi - Frontiers in physiology, 2018 - frontiersin.org
Preeclampsia is a serious complication of pregnancy where it affects 5–8% of all
pregnancies. It increases the morbidity and mortality of both the fetus and pregnant woman …

Circulating angiogenic factors and the risk of preeclampsia

RJ Levine, SE Maynard, C Qian, KH Lim… - New England journal …, 2004 - Mass Medical Soc
Background The cause of preeclampsia remains unclear. Limited data suggest that excess
circulating soluble fms-like tyrosine kinase 1 (sFlt-1), which binds placental growth factor …