Regulatory T cells (Treg cells) are a small subset of immune cells that are dedicated to
curbing excessive immune activation and maintaining immune homeostasis. Accordingly …

Abstract The interleukin (IL)-2–IL-2 receptor (IL-2R) pathway is important in immunity, but is
also involved in maintenance of self-tolerance. This paradox is further complicated by …

Acute graft-versus-host disease (aGVHD) is associated with high risk of morbidity and
mortality and is a common complication after double umbilical cord blood (UCB) …

Risk factors for acute GVHD (AGVHD), overall survival, and transplant-related mortality were
evaluated in adults receiving allogeneic hematopoietic cell transplants (1999-2005) from …

Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon,
inevitable in kidney transplantation and one of the most important mechanisms for non-or …

The potent immunosuppressive action of rapamycin is commonly ascribed to inhibition of
growth factor-induced T cell proliferation. However, it is now evident that the …

Highlights•Solid organ transplantation (SOT) patients or patients with active ADs have been
largely excluded from ICIs clinical trials because of the risk of allograft rejection or severe …

Abstract CD4+ CD25+ FOXP3+ T regulatory cells (Tregs) are pivotal for the induction and
maintenance of peripheral tolerance in both mice and humans. Rapamycin has been shown …

In recent years, monoclonal antibodies (mAbs) able to reinvigorate antitumor T-cell immunity
have heralded a paradigm shift in cancer treatment. The most high profile of these mAbs …

High-dose, posttransplantation cyclophosphamide (PTCy) is an effective strategy for
preventing graft-versus-host disease (GVHD) after allogeneic blood or marrow …