Microbiology research has recently undergone major developments that have led to great
progress towards obtaining an integrated view of microbial cell function. Microbial genetics …

Diversity in adaptive responses is common within species and populations, especially when
the heterogeneity of the frequently large populations found in environments is considered …

After hundreds of generations of adaptive evolution at exponential growth, Escherichia coli
grows as predicted using flux balance analysis (FBA) on genome‐scale metabolic models …

The causes and mechanisms of evolutionary diversification are central issues in biology.
Geographic isolation is the traditional explanation for diversification, but recent theoretical …

Microbes face a trade-off between being metabolically independent and relying on
neighboring organisms for the supply of some essential metabolites. This balance of …

Background. In patients with cystic fibrosis (CF), the emergence of hypermutable
Pseudomonas aeruginosa drives the selection of P. aeruginosa variants that are efficiently …

To grow and divide, cells must extract resources from dynamic and unpredictable
environments. Many organisms use different metabolic strategies for distinct contexts …

The mechanisms for the origin and maintenance of biological diversity are not fully
understood. It is known that frequency-dependent selection, generating advantages for rare …

Background Predicting adaptive trajectories is a major goal of evolutionary biology and
useful for practical applications. Systems biology has enabled the development of genome …

Microbial ecosystem modeling is complicated by the large number of unknown parameters
and the lack of appropriate calibration tools. Here we present a novel computational …