Crystallography supplies unparalleled detail on structural information critical for mechanistic
analyses; however, it is restricted to describing low energy conformations of …

Coarse-grained models for proteins and biomolecular aggregates have recently enjoyed
renewed interest. Coarse-grained representations combined with enhanced computer …

Cryoelectron microscopy of biological molecules is among the hottest growth areas in
biophysics and structural biology at present, and Frank is arguably the most distinguished …

Exploring recent developments in the field, Coarse-Graining of Condensed Phase and
Biomolecular Systems examines systematic ways of constructing coarse-grained …

Various types of large-amplitude molecular deformation are ubiquitously involved in the
functions of biological macromolecules, especially supramolecular complexes. They can be …

Motivation: Dynamic simulations of systems with biologically relevant sizes and time scales
are critical for understanding macromolecular functioning. Coarse-grained representations …

Decoding is the key step during protein synthesis that enables information transfer from RNA
to protein, a process critical for the survival of all organisms. We have used large-scale …

Structures of macromolecular complexes are necessary for a mechanistic description of
biochemical and cellular processes. They can be solved by experimental methods, such as …

Chlorine atoms (Cl) are highly reactive toward hydrocarbons in the Earth's troposphere,
including the greenhouse gas methane (CH4). However, the regional and global CH4 sink …

Computational studies of large macromolecular assemblages have come a long way during
the past 10 years. With the explosion of computer power and parallel computing, timescales …