NLRP3 inflammasome in neurological diseases, from functions to therapies

L Song, L Pei, S Yao, Y Wu, Y Shang - Frontiers in cellular …, 2017 - frontiersin.org
Neuroinflammation has been identified as a causative factor of multiple neurological
diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat-and pyrin …

Gas‐generating nanoplatforms: material chemistry, multifunctionality, and gas therapy

L Yu, P Hu, Y Chen - Advanced Materials, 2018 - Wiley Online Library
The fast advances of theranostic nanomedicine enable the rational design and construction
of diverse functional nanoplatforms for versatile biomedical applications, among which gas …

Hydrogen, a novel therapeutic molecule, regulates oxidative stress, inflammation, and apoptosis

Y Tian, Y Zhang, Y Wang, Y Chen, W Fan… - Frontiers in …, 2021 - frontiersin.org
Molecular hydrogen (H2) is a colorless and odorless gas. Studies have shown that H2
inhalation has the therapeutic effects in many animal studies and clinical trials, and its …

Apelin-13/APJ system attenuates early brain injury via suppression of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and oxidative …

W Xu, T Li, L Gao, J Zheng, J Yan, J Zhang… - Journal of …, 2019 - Springer
Background Neuroinflammation and oxidative stress play important roles in early brain
injury following subarachnoid hemorrhage (SAH). This study is the first to show that …

INT-777 attenuates NLRP3-ASC inflammasome-mediated neuroinflammation via TGR5/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats

X Hu, J Yan, L Huang, C Araujo, J Peng, L Gao… - Brain, behavior, and …, 2021 - Elsevier
Background Inflammasome-mediated neuroinflammation plays an important role in the
pathogenesis of early brain injury (EBI) following subarachnoid hemorrhage (SAH). The …

Hydrogen gas from inflammation treatment to cancer therapy

Y Wu, M Yuan, J Song, X Chen, H Yang - ACS nano, 2019 - ACS Publications
Hydrogen (H2) therapy is a highly promising strategy against several diseases due to its
inherent biosafety. However, the current H2 treatment modalities rely predominantly on the …

Update on nanoparticle-based drug delivery system for anti-inflammatory treatment

H Wang, Y Zhou, Q Sun, C Zhou, S Hu… - … in Bioengineering and …, 2021 - frontiersin.org
Nanobiotechnology plays an important role in drug delivery, and various kinds of
nanoparticles have demonstrated new properties, which may provide opportunities in …

Melatonin: A review of its potential functions and effects on neurological diseases

M Gunata, H Parlakpinar, HA Acet - Revue neurologique, 2020 - Elsevier
Background The aging process is not univocal, both body and brain age. Neurological
disorders are a major cause of disability and death worldwide. According to the Global …

Beneficial biological effects and the underlying mechanisms of molecular hydrogen-comprehensive review of 321 original articles

M Ichihara, S Sobue, M Ito, M Ito, M Hirayama… - Medical gas …, 2015 - Springer
Therapeutic effects of molecular hydrogen for a wide range of disease models and human
diseases have been investigated since 2007. A total of 321 original articles have been …

[HTML][HTML] Molecular hydrogen: a preventive and therapeutic medical gas for various diseases

L Ge, M Yang, NN Yang, XX Yin, WG Song - Oncotarget, 2017 - ncbi.nlm.nih.gov
Since the 2007 discovery that molecular hydrogen (H 2) has selective antioxidant properties,
multiple studies have shown that H 2 has beneficial effects in diverse animal models and …