Synthetic biology is the discipline of engineering application-driven biological functionalities
that were not evolved by nature. Early breakthroughs of cell engineering, which were based …

Synthetic biology is bringing together engineers and biologists to design and build novel
biomolecular components, networks and pathways, and to use these constructs to rewire …

INTRODUCTION Cells respond to their environment, make decisions, build structures, and
coordinate tasks. Underlying these processes are computational operations performed by …

Gene expression is a fundamentally stochastic process, with randomness in transcription
and translation leading to cell-to-cell variations in mRNA and protein levels. This variation …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

Transcription regulation networks control the expression of genes. The transcription
networks of well-studied microorganisms appear to be made up of a small set of recurring …

INTRODUCTION Although recent advances in DNA synthesis and sequencing technologies
have made practical the writing and readout of arbitrary data in the form of synthetic DNA …

Recent progress in DNA manipulation and gene circuit engineering has greatly improved
our ability to programme and probe mammalian cell behaviour. These advances have led to …

Edge detection is a signal processing algorithm common in artificial intelligence and image
recognition programs. We have constructed a genetically encoded edge detection algorithm …

A more complete understanding of the causes and effects of cell-cell variability in gene
expression is needed to elucidate whether the resulting phenotypes are disadvantageous or …