The myelination of axons has evolved to enable fast and efficient transduction of electrical
signals in the vertebrate nervous system. Acting as an electric insulator, the myelin sheath is …

Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …

Recent understanding of how the systemic environment shapes the brain throughout life has
led to numerous intervention strategies to slow brain ageing,–. Cerebrospinal fluid (CSF) …

Neurological disorders are the leading cause of physical and cognitive disability across the
globe, currently affecting approximately 15% of the worldwide population [1]. Absolute …

Throughout our lifespan, new sensory experiences and learning continually shape our
neuronal circuits to form new memories. Plasticity at the level of synapses has been …

Myelin degeneration occurs in neurodegenerative diseases and aging. In these conditions,
resident oligodendrocyte progenitor cells (OPCs) differentiate into oligodendrocytes that …

Myelin, a lipid membrane that wraps axons, enabling fast neurotransmission and metabolic
support to axons, is conventionally thought of as a static structure that is set early in …

Despite the large number of immunomodulatory or immunosuppressive treatments available
to treat relapsing–remitting multiple sclerosis (MS), treatment of the progressive phase of the …

Myelin, which is produced by oligodendrocytes, insulates axons to facilitate rapid and
efficient action potential propagation in the central nervous system. Traditionally viewed as a …

Multiple sclerosis (MS) is a neurological disease characterized by multifocal lesions and
smoldering pathology. Although single-cell analyses provided insights into cytopathology …