Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction
MC Haigis, LP Guarente - Genes & development, 2006 - genesdev.cshlp.org
Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast,
worms and flies. Mammals contain seven homologs of yeast Sir2, SIRT1–7. Here, we review …
worms and flies. Mammals contain seven homologs of yeast Sir2, SIRT1–7. Here, we review …
The role of mitochondrial function in the oocyte and embryo
Mitochondria have long been known to be the powerhouses of the cell but they also
contribute to redox and Ca 2+ homeostasis, provide intermediary metabolites and store …
contribute to redox and Ca 2+ homeostasis, provide intermediary metabolites and store …
[HTML][HTML] The NAD+ precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity
As NAD+ is a rate-limiting cosubstrate for the sirtuin enzymes, its modulation is emerging as
a valuable tool to regulate sirtuin function and, consequently, oxidative metabolism. In line …
a valuable tool to regulate sirtuin function and, consequently, oxidative metabolism. In line …
The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells
Recent studies have revealed new roles for NAD and its derivatives in transcriptional
regulation. The evolutionarily conserved Sir2 protein family requires NAD for its deacetylase …
regulation. The evolutionarily conserved Sir2 protein family requires NAD for its deacetylase …
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases
S Imai, L Guarente - Trends in pharmacological sciences, 2010 - cell.com
Since the discovery of NAD-dependent deacetylase activity of the silent information
regulator-2 (SIR2) family ('sirtuins'), many exciting connections between protein …
regulator-2 (SIR2) family ('sirtuins'), many exciting connections between protein …
SIRT1 and p53, effect on cancer, senescence and beyond
NAD+-dependent Class III histone deacetylase SIRT1 is a multiple function protein critically
involved in stress responses, cellular metabolism and aging through deacetylating a variety …
involved in stress responses, cellular metabolism and aging through deacetylating a variety …
Sirtuins: The 'magnificent seven', function, metabolism and longevity
N Dali‐Youcef, M Lagouge, S Froelich, C Koehl… - Annals of …, 2007 - Taylor & Francis
The sirtuin family of histone deacetylases (HDACs) was named after their homology to the
Saccharomyces cerevisiae gene silent information regulator 2 (Sir2). In the yeast, Sir2 has …
Saccharomyces cerevisiae gene silent information regulator 2 (Sir2). In the yeast, Sir2 has …
SIRT6 protects against pathological damage caused by diet‐induced obesity
Y Kanfi, V Peshti, R Gil, S Naiman, L Nahum… - Aging cell, 2010 - Wiley Online Library
The NAD+‐dependent SIRT6 deacetylase is a therapeutic candidate against the emerging
metabolic syndrome epidemic. SIRT6, whose deficiency in mice results in premature aging …
metabolic syndrome epidemic. SIRT6, whose deficiency in mice results in premature aging …
Redox-dependent transcriptional regulation
H Liu, R Colavitti, II Rovira, T Finkel - Circulation research, 2005 - Am Heart Assoc
Reactive oxygen species contribute to the pathogenesis of a number of disparate disorders
including tissue inflammation, heart failure, hypertension, and atherosclerosis. In response …
including tissue inflammation, heart failure, hypertension, and atherosclerosis. In response …
Prokaryotic homologs of Argonaute proteins are predicted to function as key components of a novel system of defense against mobile genetic elements
Background In eukaryotes, RNA interference (RNAi) is a major mechanism of defense
against viruses and transposable elements as well of regulating translation of endogenous …
against viruses and transposable elements as well of regulating translation of endogenous …